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GW 284543 hydrochloride

Catalog No. T7742 CAS 179246-08-3

GW 284543 hydrochloride is a selective inhibitor of <a href="/target/MEK" style="display: inline; color: #c13a36">MEK</a>5 .

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

GW 284543 hydrochloride, CAS 179246-08-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
2 mg	In stock	$ 68.00
5 mg	In stock	$ 96.00
10 mg	In stock	$ 173.00
25 mg	In stock	$ 333.00
50 mg	In stock	$ 567.00
200 mg	In stock	$ 997.00
500 mg	In stock	$ 1,949.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

GW 284543 hydrochloride is a selective inhibitor of MEK5 .

Molecular Weight	408.88
Formula	C23H21ClN2O3
CAS No.	179246-08-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 2.5 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Vaseva AV, Blake DR, Gilbert TSK,et al.KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism[J].Cancer Cell. 2018 Nov 12;34(5):807-822.e7.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Ovarian Cancer Compound Library Anti-Cancer Compound Library Anti-Liver Cancer Compound Library Anti-Prostate Cancer Compound Library Kinase Inhibitor Library Inhibitor Library Anti-Pancreatic Cancer Compound Library MAPK Inhibitor Library Bioactive Compound Library HIF-1 Signaling Pathway Compound Library

Related Products

Related compounds with same targets

Uncarinic acid E Griffipavixanthone Corylifol C Boehmenan Alpinumisoflavone Cajanin anemarsaponin B BMS-599626

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GW 284543 hydrochloride 179246-08-3 MAPK MEK Inhibitor inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.