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GSK299423

Catalog No. T32008 CAS 1352149-24-6

Synonyms: GSK-299423, GSK 299423

GSK299423 (GlaxoSmithKline 299423) is an antibiotic that may have therapeutic effect in patients infected with bacteria expressing New Delhi metal-β-lactamase. Antibiotics inhibit the topoisomerases that the bacteria need to replicate.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

GSK299423, CAS 1352149-24-6

Pack Size	Availability	Price/USD	Quantity
5 mg	In stock	$ 2,698.00

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Purity: 97.46%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	GSK-299423, GSK 299423
Molecular Weight	461.58
Formula	C25H27N5O2S
CAS No.	1352149-24-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Mudeppa DG, Kumar S, Kokkonda S, White J, Rathod PK. Topoisomerase II from Human Malaria Parasites: EXPRESSION, PURIFICATION, AND SELECTIVE INHIBITION. J Biol Chem. 2015 Aug 14;290(33):20313-24. doi: 10.1074/jbc.M115.639039. Epub 2015 Jun 8. PubMed PMID: 26055707; PubMed Central PMCID: PMC4536438. 2. Vos SM, Lyubimov AY, Hershey DM, Schoeffler AJ, Sengupta S, Nagaraja V, Berger JM. Direct control of type IIA topoisomerase activity by a chromosomally encoded regulatory protein. Genes Dev. 2014 Jul 1;28(13):1485-97. doi: 10.1101/gad.241984.114. PubMed PMID: 24990966; PubMed Central PMCID: PMC4083091. 3. Singh SB, Kaelin DE, Wu J, Miesel L, Tan CM, Meinke PT, Olsen D, Lagrutta A, Bradley P, Lu J, Patel S, Rickert KW, Smith RF, Soisson S, Wei C, Fukuda H, Kishii R, Takei M, Fukuda Y. Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents. ACS Med Chem Lett. 2014 Mar 12;5(5):609-14. doi: 10.1021/ml500069w. eCollection 2014 May 8. PubMed PMID: 24900889; PubMed Central PMCID: PMC4027601. 4. Bax BD, Chan PF, Eggleston DS, Fosberry A, Gentry DR, Gorrec F, Giordano I, Hann MM, Hennessy A, Hibbs M, Huang J, Jones E, Jones J, Brown KK, Lewis CJ, May EW, Saunders MR, Singh O, Spitzfaden CE, Shen C, Shillings A, Theobald AJ, Wohlkonig A, Pearson ND, Gwynn MN. Type IIA topoisomerase inhibition by a new class of antibacterial agents. Nature. 2010 Aug 19;466(7309):935-40. doi: 10.1038/nature09197. Epub 2010 Aug 4. PubMed PMID: 20686482.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GSK299423 1352149-24-6 GSK-299423 GSK 299423 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.