Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GB1107 is an effective and selective Galectin-3 inhibitor with a Kd of 37 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 53.00 | |
5 mg | In stock | $ 128.00 | |
10 mg | In stock | $ 189.00 | |
25 mg | In stock | $ 315.00 | |
50 mg | In stock | $ 468.00 | |
100 mg | In stock | $ 686.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 147.00 |
Description | GB1107 is an effective and selective Galectin-3 inhibitor with a Kd of 37 nM. |
Targets&IC50 | human Gal-3:(kd)37 nM |
In vitro | GB1107 (0-1 μM) increases CD8+ T cell infiltration and tumor M1 macrophage polarization. GB1107 potentiates the effects of a PD-L1 immune checkpoint inhibitor to increase the expression of cytotoxic and apoptotic effector molecules including perforin-1, Fas ligand, IFN-γ, granzyme B, and cleaved caspase-3[1]. |
In vivo | In CD-1 nude female mice received 3x106 human lung adenocarcinoma cells (A549), GB1107 (10 mg/kg, p.o.) significantly reduces tumor growth and final tumor weights[1]. |
Synonyms | (2R,3R,4S,5R,6R)-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-4-[4-(3,4,5-trifluorophenyl)triazol-1-yl]oxane-3,5-diol |
Molecular Weight | 522.32 |
Formula | C20H16Cl2F3N3O4S |
CAS No. | 1978336-61-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (86.15 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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GB1107 1978336-61-6 Immunology/Inflammation Galectin GB 1107 (2R,3R,4S,5R,6R)-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-4-[4-(3,4,5-trifluorophenyl)triazol-1-yl]oxane-3,5-diol GB-1107 inhibitor inhibit