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Forasartan

Catalog No. T31845 CAS 145216-43-9

Synonyms: SC52458, SC 52458, SC-52458

Forasartan is a non - peptide angiotensin II receptor antagonist with antihypertensive activity. Forasartan and angiotensin II compete to bind AT1 receptor subtypes in vascular smooth muscle, thereby blocking angiotensin II-mediated vasoconstriction, leading to vasodilation. In addition, antagonism against AT1 in the adrenal gland prevents angiotensin II-induced adrenal cortical synthesis and aldosterone secretion stimulation.

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Forasartan, CAS 145216-43-9

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	SC52458, SC 52458, SC-52458
Molecular Weight	416.52
Formula	C23H28N8
CAS No.	145216-43-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Kushiku K, Yamada H, Shibata K, Tokunaga R, Katsuragi T, Furukawa T. Upregulation of immunoreactive angiotensin II release and angiotensinogen mRNA expression by high-frequency preganglionic stimulation at the canine cardiac sympathetic ganglia. Circ Res. 2001 Jan 19;88(1):110-6. PubMed PMID: 11139482. 2. Aki Y, Tomohiro A, Nishiyama A, Kiyomoto K, Kimura S, Abe Y. The role of basally synthesized nitric oxide in modulating the renal vasoconstrictor action of angiotensin II. Hypertens Res. 1997 Dec;20(4):251-6. PubMed PMID: 9453259. 3. McMahon EG, Yang PC, Babler MA, Suleymanov OD, Palomo MA, Olins GM, Cook CS. Effects of SC-52458, an angiotensin AT1 receptor antagonist, in the dog. Am J Hypertens. 1997 Jun;10(6):671-7. PubMed PMID: 9194514. 4. Usune S, Furukawa T. Effects of SC-52458, a new nonpeptide angiotensin II receptor antagonist, on increase in cytoplasmic Ca2+ concentrations and contraction induced by angiotensin II and K(+)-depolarization in guinea-pig taenia coli. Gen Pharmacol. 1996 Oct;27(7):1179-85. PubMed PMID: 8981065.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Forasartan 145216-43-9 SC52458 SC 52458 SC-52458 inhibitor inhibit

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