Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fmoc-Val-Ala-PAB-OH (Fmoc-Val-Ala-PAB) is a useful linker for making Antibody-Drug-Conjugation (ADC) conjugate for targeting drug delivery. It is also utilized in the synthesis of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 44.00 | |
50 mg | In stock | $ 66.00 | |
100 mg | In stock | $ 97.00 |
Description | Fmoc-Val-Ala-PAB-OH (Fmoc-Val-Ala-PAB) is a useful linker for making Antibody-Drug-Conjugation (ADC) conjugate for targeting drug delivery. It is also utilized in the synthesis of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers. |
In vivo | Osilodrostat and pasireotide monotherapies can significantly affect in the histology and mean weights of the pituitary and adrenal glands, liver, and ovary/oviduct. Osilodrostat is associated with adrenocortical hypertrophy and hepatocellular hypertrophy. The combination of Osilodrostat with pasireotide ameliorates the liver and adrenal gland changes observed with monotherapy and does not exacerbate any target organ changes. Cmax and AUC(0–24h) of Osilodrostat and pasireotide increase in an approximately dose-proportional manner. Osilodrostat treatment reduces urinary free cortisol in patients with Cushing's disease; 78.9% has normal urinary free cortisol at week 22. |
Synonyms | Fmoc-Val-Ala-PAB |
Molecular Weight | 515.6 |
Formula | C30H33N3O5 |
CAS No. | 1394238-91-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mM
You can also refer to dose conversion for different animals. More
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Fmoc-Val-Ala-PAB-OH 1394238-91-5 Neuroscience Others AChR Fmoc-Val-Ala-PAB Inhibitor Antibody-drug conjugates linkers ADC Linkers Fmoc Val Ala PAB OH inhibit FmocValAlaPABOH inhibitor