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Finasteride acetate

Catalog No. T21668 CAS 222989-99-3

Finasteride (MK-906) acetate is a potent and competitive 5α-reductase inhibitor, with an IC 50 of 4.2 nM for type II 5α-reductase. The affinity of Finasteride acetate for type II 5α-reductase enzyme was approximately 100-fold higher than that for the type I enzyme. Finasteride acetate can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia [1] [2] [3].

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Finasteride acetate, CAS 222989-99-3

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 2,140.00
50 mg	6-8 weeks	$ 2,785.00
100 mg	6-8 weeks	$ 3,520.00

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Biological Description

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Description	Finasteride (MK-906) acetate is a potent and competitive 5α-reductase inhibitor, with an IC 50 of 4.2 nM for type II 5α-reductase. The affinity of Finasteride acetate for type II 5α-reductase enzyme was approximately 100-fold higher than that for the type I enzyme. Finasteride acetate can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia [1] [2] [3].
In vitro	Finasteride, at a concentration of 10 μM over incubation periods of 6 to 24 hours, induces the expression of HO-1 and Nrf2 proteins in PC-3 cells, and also inhibits the conversion of [3 H]testosterone (T) to [3 H]dihydrotestosterone (DHT) in P. crustosum. In cell viability assays involving PC-3, DU-145, and LNCaP cell lines treated with finasteride at 10 μM for durations of 6, 12, and 24 hours, there was a noticeable increase in HO-1 protein expression in a time-dependent manner specifically in PC-3 cells. Additionally, finasteride triggered the expression of Nrf2 protein in DU-145 and PC-3 cells, though not in LNCaP cells.
In vivo	Finasteride, administered orally at a dosage of 0.1-0.5 mg/kg once daily for 16 weeks, effectively reduces prostatic size in male dogs aged 2.7-11 years and weighing 10.3-49 kg with spontaneous benign prostatic hyperplasia (BPH), as indicated by a decrease in prostatic diameter (20%), volume (43%), and serum dihydrotestosterone (DHT) concentration (58%). This treatment does not negatively impact semen quality or serum testosterone levels and is free from adverse effects on the animals [3].

Molecular Weight	432.605
Formula	C25H40N2O4
CAS No.	222989-99-3

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Finasteride acetate 222989-99-3 Finasteride Acetate inhibitor inhibit

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