Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ferroquine (Ferrochloroquine) is a ferrocenyl analogue of Chloroquine with antimalarial activity. Ferroquine induces oxidative stress and the subsequent destruction of the membrane, resulting in parasiticidal effect on Plasmodium.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 123.00 | |
25 mg | In stock | $ 247.00 | |
50 mg | In stock | $ 422.00 | |
100 mg | In stock | $ 628.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 68.00 |
Description | Ferroquine (Ferrochloroquine) is a ferrocenyl analogue of Chloroquine with antimalarial activity. Ferroquine induces oxidative stress and the subsequent destruction of the membrane, resulting in parasiticidal effect on Plasmodium. |
In vitro | All newly transformed schistosomula (NTS) exposed to 33.3 µM hydroxyl-ferroquine (FQ-OH), Ferroquine (FQ), and Ruthenoquine (RQ) displays strongly decrease liabilities, after 24 hours post-incubation. All NTS exposed to 33.3 µM RQ have died, while Ferroquine and FQ-OH treated worms are strongly affected but still alive, after 72 hours post-incubation [1]. |
In vivo | Ferroquine (200 and 800 mg/kg; mice ) treatment, displays low total worm burden reductions of 19.4% and 35.6%. One of the mice treated with 800 mg/kg Ferroquine died within 24 hours post-treatment. No activity is observed treating mice with Ruthenoquine at 200 mg/kg. Hence, modification of Chloroquine (CQ) by a ferrocenyl or ruthenocenyl fragment does not increase the antischistosomal properties of CQ. A total worm burden reduction of 17.3% is observed following treatment with hydroxyl-ferroquine. Furthermore, in one of the hydroxyl-ferroquine treated mice many dead worms are recovered and a hepatic shift (i.e. worms migrating to the liver) observed. Hence, Ferroquine and hydroxyl-ferroquine show weak antischistosomal activity in vivo[1]. |
Synonyms | SSR97193, Ferrochloroquine |
Molecular Weight | 433.76 |
Formula | C23H24ClFeN3 |
CAS No. | 185055-67-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 7.5 mg/mL (17.3 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Ferroquine 185055-67-8 Others SSR97193 SSR 97193 SSR-97193 Ferrochloroquine inhibitor inhibit