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FASN-IN-3 is an inhibitor of fatty acid synthase (FASN).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | 56 € | In Stock | |
5 mg | 135 € | In Stock | |
10 mg | 218 € | In Stock | |
25 mg | 372 € | In Stock | |
50 mg | 508 € | In Stock | |
100 mg | 723 € | In Stock | |
200 mg | 937 € | In Stock | |
1 mL x 10 mM (in DMSO) | 150 € | In Stock |
Description | FASN-IN-3 is an inhibitor of fatty acid synthase (FASN). |
In vitro | For monocytes, FASN-IN-3 treatment reduces the level of IL-1 beta resulting from LTA stimulation whereas there is only a slight reduction after LPS stimulation.Human PBMC and monocytes in cell cultures are stimulated with lipopolysaccharide (LPS), a Toll 4 receptor agonist, or lipoteichoic acid (LTA), a Toll 2 receptor agonist. Stimulation with either LPS or LTA plus DMSO, the solvent for FASN-IN-3 , results in secretion of IL-1 beta. FASN inhibitor 1 treatment of PBMC, which is a mixed population of mononuclear cells including both lymphocytes and monocytes, reduces the level of IL-1 beta resulting from either LPS or LTA stimulation. |
Molecular Weight | 384.47 |
Formula | C24H24N4O |
Cas No. | 2097262-60-5 |
Smiles | Cc1n[nH]c(c1C)-c1cc(C(=O)N2CC(C2)c2ccc(cc2)C#N)c(C)cc1C |
Relative Density. | 1.26 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 33.33 mg/mL (86.69 mM), Sonication and heating to 80℃ are recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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