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Erythro-sphingosine, (+)-

Catalog No. T24044 CAS 6036-75-5

Synonyms: L-Erythro-c18-sphingosine, L-Erythro-sphingosine

Erythro-sphingosine, (+)- is a cell-permeable and reversible inhibitor of protein kinase C (IC50: 12 μM) and enhances Src kinase activity.

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Erythro-sphingosine, (+)- Chemical Structure

Erythro-sphingosine, (+)-, CAS 6036-75-5

Pack Size	Availability	Price/USD	Quantity
500 μg	35 days	$ 198.00
1 mg	35 days	$ 380.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Erythro-sphingosine, (+)- is a cell-permeable and reversible inhibitor of protein kinase C (IC50: 12 μM) and enhances Src kinase activity.

Synonyms	L-Erythro-c18-sphingosine, L-Erythro-sphingosine
Molecular Weight	299.49
Formula	C18H37NO2
CAS No.	6036-75-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Kong JN, Zhu Z, Itokazu Y, Wang G, Dinkins MB, Zhong L, Lin HP, Elsherbini A, Leanhart S, Jiang X, Qin H, Zhi W, Spassieva SD, Bieberich E. Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes. J Lipid Res. 2018 Mar;59(3):488-506. doi: 10.1194/jlr.M081877. Epub 2018 Jan 10. PubMed PMID: 29321137; PubMed Central PMCID: PMC5832933. 2. Molinski TF, Broaddus CD, Morinaka BI. Liposomal Circular Dichroism (L-CD) of Arenoyl Derivatives of Sphingolipids. Amplification of Cotton Effects in Ordered Lipid Bilayers. Mar Drugs. 2017 Dec 20;15(12). pii: E352. doi: 10.3390/md15120352. PubMed PMID: 29261105; PubMed Central PMCID: PMC5742824. 3. Hassouneh LK, Timofiychuk OA, Babenko NA. Acid sphingomyelinase inhibitors, imipramine and zoledronic acid, increase skeletal muscle tissue sensitivity to insulin action at old age. Gen Physiol Biophys. 2018 Mar;37(2):163-174. doi: 10.4149/gpb_2017020. Epub 2017 Nov 10. PubMed PMID: 29125130. 4. Paz Ramos A, Gooris G, Bouwstra J, Lafleur M. Evidence of hydrocarbon nanodrops in highly ordered stratum corneum model membranes. J Lipid Res. 2018 Jan;59(1):137-143. doi: 10.1194/jlr.M080432. Epub 2017 Nov 1. PubMed PMID: 29092959; PubMed Central PMCID: PMC5748504.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Erythro-sphingosine, (+)- 6036-75-5 L-Erythro-c18-sphingosine Erythro-sphingosine, L-Erythro-sphingosine Erythrosphingosine, (+) Erythro sphingosine, (+) inhibitor inhibit

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