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Epothilone D

Name: Epothilone D
Brand: TargetMol
SKU: TQ0202
Rating: 4.5 (1 reviews)

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Catalog No. TQ0202Cas No. 189453-10-9

Alias Utidelone, UTD1, UTD 1, KOS862, KOS 862

Epothilone D is a natural polyketide compound isolated from the myxobacterium Sorangium cellulosum that binds to tubulin and inhibits microtubule disassembly, thereby blocking mitosis, cellular proliferation, and cell motility, Epothilone D is extensively utilized in cancer research to study microtubule dynamics, mitotic arrest, and cytoskeleton-targeted anticancer mechanisms.

Epothilone D

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Catalog No. TQ0202Alias Utidelone, UTD1, UTD 1, KOS862, KOS 862Cas No. 189453-10-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$50	6-8 weeks	6-8 weeks
5 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Epothilone D is a natural polyketide compound isolated from the myxobacterium Sorangium cellulosum that binds to tubulin and inhibits microtubule disassembly, thereby blocking mitosis, cellular proliferation, and cell motility, Epothilone D is extensively utilized in cancer research to study microtubule dynamics, mitotic arrest, and cytoskeleton-targeted anticancer mechanisms.
In vitro	Epothilone D is a more potent microtubule stabilizer in vitro than epothilone A or B. In vitro, Epothilone D has shown potent cytotoxicity in a panel of human tumor cell lines, with similar potency to paclitaxel. Epothilone D also shows a definite advantage over paclitaxel in drug-resistant cell lines and retained its cytotoxicity against a multidrug-resistant cell line over-expressing P-glycoprotein [1].
In vivo	In a transgenic mouse model of Tauopathy (PS19 mice), which mimics features of Alzheimer's disease, intraperitoneal (i.p.) administration of Epothilone D (1 mg/kg or 3 mg/kg, weekly for 3 months) affected microtubule density and axonal integrity. These structural changes were associated with improvements in cognitive measures in the treated mice. At these dosages, the mice did not exhibit weight loss or neutropenia, indicating a tolerance profile distinct from higher chemotherapeutic doses [2].
Animal Research	Groups of mice (n=3) receive intraperitoneal (i.p.) injections of 3.7 mg/kg of Epothilone D (epoD) dissolved in 100% DMSO, followed by euthanization using approved at times ranging from 0.25 h to 24 h. In another study, groups of mice (n=3) receive injections of 3 mg/kg of epoD in 100% DMSO followed by euthanization 4, 6 and 10 days later. The Epothilone D (epoD) levels in the brain and blood samples are determined using LC-MS/MS protocols. Groups (n=10-13) of 3-month old PS19 tau Tg mice or 3-month old non-Tg littermates are administered weekly i.p. injections of 1 mg/kg epoD, 3 mg/kg of Epothilone D (epoD) or vehicle (DMSO), for a total of 3 months. Animals are monitored for signs of abnormal behavior or distress and are weighed weekly. After final dosing, the mice undergo motor function and cognitive testing. After euthanization, brains and optic nerve (ON) are recovered for immunohistochemical analyses. A subset of mice from each group also undergo necropsy evaluation with organ weights recorded [2].
Synonyms	Utidelone, UTD1, UTD 1, KOS862, KOS 862

Chemical Properties

Molecular Weight	489.72
Formula	C₂₈H₄₃NO₄S
Cas No.	189453-10-9
Smiles	CC(C)(C([C@@H]([C@H]([C@H](CCC/C(C)=C/C[C@H](O1)/C(C)=C/C2=CSC(C)=N2)C)C)C)=O)[C@H](CC1=O)O
Relative Density.	1.084 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (163.36 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (6.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0420 mL	10.2099 mL	20.4198 mL	102.0992 mL
5 mM	0.4084 mL	2.0420 mL	4.0840 mL	20.4198 mL
10 mM	0.2042 mL	1.0210 mL	2.0420 mL	10.2099 mL
20 mM	0.1021 mL	0.5105 mL	1.0210 mL	5.1050 mL
50 mM	0.0408 mL	0.2042 mL	0.4084 mL	2.0420 mL
100 mM	0.0204 mL	0.1021 mL	0.2042 mL	1.0210 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc