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Eperezolid

Catalog No. T15237 CAS 165800-04-4

Synonyms: PNU-100592

Eperezolid (PNU-100592) is an oxazolidinone antibacterial agent. Eperezolid showed well in vitro inhibitory activity, regardless of methicillin susceptibility for staphylococci(MIC90= 1-4 mg/ml).

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Eperezolid, CAS 165800-04-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 115.00
5 mg	In stock	$ 287.00
10 mg	In stock	$ 432.00
25 mg	In stock	$ 716.00
50 mg	In stock	$ 987.00
100 mg	In stock	$ 1,370.00
500 mg	In stock	$ 2,730.00
1 mL * 10 mM (in DMSO)	In stock	$ 313.00

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Purity: 96.18%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Eperezolid (PNU-100592) is an oxazolidinone antibacterial agent. Eperezolid showed well in vitro inhibitory activity, regardless of methicillin susceptibility for staphylococci(MIC90= 1-4 mg/ml).

In vitro

The specific binding of eperezolid is dose-dependent and is proportional to the ribosome concentrations. The binding of eperezolid to the ribosome is competitively inhibited by chloramphenicol and lincomycin. However, unlike chloramphenicol and lincomycin, eperezolid does not inhibit the puromycin reaction, indicating that the oxazolidinones have no effect on peptidyl transferase [2]. Antibiotic Eperezolid binds specifically to the 50S ribosomal subunit of Escherichia coli. eperezolid was found to bind only to the 50S subunit, with similar affinity as to the 70S ribosome, and to have no affinity for the 30S subunit [3].

Synonyms	PNU-100592
Molecular Weight	394.4
Formula	C18H23FN4O5
CAS No.	165800-04-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 44 mg/mL (111.56 mM)

References and Literature

1. Rybak MJ, et al. Comparative in vitro activities and postantibiotic effects of the oxazolidinone compounds eperezolid (PNU-100592) and linezolid (PNU-100766) versus vancomycin against Staphylococcus aureus, coagulase-negative staphylococci, Enterococcus f 2. Lin AH, et al. The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycin. Antimicrob Agents Chemother. 1997 Oct;41(10):2127-31. 3. Zhou CC, et al. 1H nuclear magnetic resonance study of oxazolidinone binding to bacterial ribosomes. Antimicrob Agents Chemother. 2002 Mar;46(3):625-9.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Infection Compound Library Human Metabolite Library ReFRAME Related Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Bacterial Compound Library Antibiotics Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Eperezolid 165800-04-4 Microbiology/Virology Antibiotic Antibacterial Bacterial PNU 100592 Inhibitor PNU100592 PNU-100592 inhibit inhibitor

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