Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Eggmanone (EGM1) is a potent, selective phosphodiesterase 4 (PDE4) antagonist, exhibiting an IC50 of 72 nM specifically for PDE4D3. It shows 40- to 50-fold greater selectivity for PDE4D3 over other phosphodiesterases. The mechanism of action involves PDE4 selective antagonism by Eggmanone, which activates protein kinase A, culminating in the blockade of the Hedgehog (Hh) signaling pathway [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 198.00 | |
5 mg | 35 days | $ 890.00 | |
10 mg | 35 days | $ 1,580.00 |
Description | Eggmanone (EGM1) is a potent, selective phosphodiesterase 4 (PDE4) antagonist, exhibiting an IC50 of 72 nM specifically for PDE4D3. It shows 40- to 50-fold greater selectivity for PDE4D3 over other phosphodiesterases. The mechanism of action involves PDE4 selective antagonism by Eggmanone, which activates protein kinase A, culminating in the blockade of the Hedgehog (Hh) signaling pathway [1]. |
Molecular Weight | 416.58 |
Formula | C20H20N2O2S3 |
CAS No. | 505068-32-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Eggmanone 505068-32-6 inhibitor inhibit