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Efaproxiral

Catalog No. T21318 CAS 131179-95-8

Synonyms: RSR13, Efaproxyn, RSR 13, RSR-13

Efaproxiral is a synthetic small molecule with radiosensitizing activity. Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity, increasing tumor oxygenation reduces tumor radioresistance.

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Efaproxiral, CAS 131179-95-8

Pack Size	Availability	Price/USD
10 mg	5 days	$ 30.00
25 mg	5 days	$ 46.00
50 mg	5 days	$ 83.00
1 mL * 10 mM (in DMSO)	5 days	$ 74.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	RSR13, Efaproxyn, RSR 13, RSR-13
Molecular Weight	341.4
Formula	C20H23NO4
CAS No.	131179-95-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: Soluble

References and Literature

1. Yi R, Sandhu J, Zhao S, Lam G, Loganathan D, Morrissey B. Detection of efaproxiral (RSR13) and its metabolites in equine by liquid chromatography tandem mass spectrometry. J Mass Spectrom. 2014 Jan;49(1):57-67. doi: 10.1002/jms.3304. PubMed PMID: 24446264. 2. Gustafsson T, PontÃ©n F, Seeberger PH. Trimethylaluminium mediated amide bond formation in a continuous flow microreactor as key to the synthesis of rimonabant and efaproxiral. Chem Commun (Camb). 2008 Mar 7;(9):1100-2. doi: 10.1039/b719603b. Epub 2008 Feb 1. PubMed PMID: 18292903. 3. Scott C, Suh J, Stea B, Nabid A, Hackman J. Improved survival, quality of life, and quality-adjusted survival in breast cancer patients treated with efaproxiral (Efaproxyn) plus whole-brain radiation therapy for brain metastases. Am J Clin Oncol. 2007 Dec;30(6):580-7. PubMed PMID: 18091051. 4. Hou H, Khan N, Grinberg OY, Yu H, Grinberg SA, Lu S, Demidenko E, Steffen RP, Swartz HM. The effects of Efaproxyn (efaproxiral) on subcutaneous RIF-1 tumor oxygenation and enhancement of radiotherapy-mediated inhibition of tumor growth in mice. Radiat Res. 2007 Aug;168(2):218-25. PubMed PMID: 17638413.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Efaproxiral 131179-95-8 RSR13 Efaproxyn RSR 13 RSR-13 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.