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Doxorubicinol

Catalog No. T25349 CAS 54193-28-1

Synonyms: RP-27706, Antibiotic 27706RP, 13-Dihydrodoxorubicin, Adriamycinol, RP 27706

Doxorubicinol is the major circulating metabolite of doxorubicin with antineoplastic acitivity.

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Doxorubicinol, CAS 54193-28-1

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Doxorubicinol is the major circulating metabolite of doxorubicin with antineoplastic acitivity.

Synonyms	RP-27706, Antibiotic 27706RP, 13-Dihydrodoxorubicin, Adriamycinol, RP 27706
Molecular Weight	545.54
Formula	C27H31NO11
CAS No.	54193-28-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Pérez-Blanco JS, Fernández de Gatta Mdel M, Hernández-Rivas JM, García Sánchez MJ, Sayalero Marinero ML, González López F. Validation and clinical evaluation of a UHPLC method with fluorescence detector for plasma quantification of doxorubicin and doxorubicinol in haematological patients. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Apr 1;955-956:93-7. doi: 10.1016/j.jchromb.2014.02.034. Epub 2014 Feb 28. PubMed PMID: 24631816. 2. Schaupp CM, White CC, Merrill GF, Kavanagh TJ. Metabolism of doxorubicin to the cardiotoxic metabolite doxorubicinol is increased in a mouse model of chronic glutathione deficiency: A potential role for carbonyl reductase 3. Chem Biol Interact. 2015 Jun 5;234:154-61. doi: 10.1016/j.cbi.2014.11.010. Epub 2014 Nov 21. PubMed PMID: 25446851; PubMed Central PMCID: PMC4414687. 3. Pérez-Blanco JS, Santos-Buelga D, Fernández de Gatta MD, Hernández-Rivas JM, Martín A, García MJ. Population pharmacokinetics of doxorubicin and doxorubicinol in patients diagnosed with non-Hodgkin's lymphoma. Br J Clin Pharmacol. 2016 Dec;82(6):1517-1527. doi: 10.1111/bcp.13070. Epub 2016 Sep 6. PubMed PMID: 27447545; PubMed Central PMCID: PMC5099548. 4. Salvatorelli E, Menna P, Paz OG, Chello M, Covino E, Singer JW, Minotti G. The novel anthracenedione, pixantrone, lacks redox activity and inhibits doxorubicinol formation in human myocardium: insight to explain the cardiac safety of pixantrone in doxorubicin-treated patients. J Pharmacol Exp Ther. 2013 Feb;344(2):467-78. doi: 10.1124/jpet.112.200568. Epub 2012 Nov 28. PubMed PMID: 23192654.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Doxorubicinol 54193-28-1 RP27706 RP-27706 Antibiotic 27706RP 13-Dihydrodoxorubicin Adriamycinol RP 27706 inhibitor inhibit

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