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Doripenem

Name: Doripenem
Brand: TargetMol
SKU: T22314
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22314Cas No. 148016-81-3

Doripenem is a new parenteral carbapenem antibiotic with broad-spectrum activity against gram-negative and gram-positive pathogens.

Doripenem

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Purity: 99.79%

Catalog No. T22314Cas No. 148016-81-3

Doripenem is a new parenteral carbapenem antibiotic with broad-spectrum activity against gram-negative and gram-positive pathogens.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$44	In Stock	In Stock
25 mg	$73	In Stock	In Stock
50 mg	$123	In Stock	In Stock
100 mg	$178	In Stock	In Stock
500 mg	$445	Inquiry	Inquiry
1 g	$653	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.79%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Doripenem AI Summary

Doripenem exhibits broad-spectrum antimicrobial activity against a variety of bacterial strains, including multidrug-resistant pathogens. It demonstrates effectiveness against Acinetobacter baumannii (including isolates producing OXA-23, IMP-4, and KPC beta-lactamases), Pseudomonas aeruginosa (including oprD-deficient and multidrug-resistant isolates), Escherichia coli, Klebsiella pneumoniae (including ESBL- and carbapenemase-producing strains), Clostridium difficile, and several anaerobes such as Bacteroides and Fusobacterium species. The MIC values for Doripenem vary widely depending on the bacterial strain, ranging from as low as 0.015 μg/mL to greater than 128 μg/mL. Doripenem has been shown to exhibit significant bactericidal activity, with high killing rates at MIC and 2xMIC levels for various bacterial strains. It also demonstrates potent inhibition of penicillin-binding proteins (PBPs) in E. coli and P. aeruginosa, and activity against enzymes such as CTX-M-15, CTX-M-71, and Mycobacterium tuberculosis LdtMt1. Moreover, the compound displays time-dependent pharmacokinetics, with favorable T>MIC values and pharmacokinetic parameters, including distribution, clearance, and half-life, in both healthy individuals and patients with renal impairment. In addition to antibacterial properties, Doripenem also shows some antiviral activity against SARS-CoV-2, inhibiting the virus-induced cytotoxicity in cell assays. The compound has demonstrated minimal liver toxicity but is associated with various adverse effects like gastrointestinal symptoms and headaches when administered intravenously. Overall, Doripenem holds promise as an antimicrobial agent, especially for treating severe and multidrug-resistant bacterial infections, though careful monitoring during treatment is advised..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Doripenem is a new parenteral carbapenem antibiotic with broad-spectrum activity against gram-negative and gram-positive pathogens.

Chemical Properties

Molecular Weight	420.5
Formula	C₁₅H₂₄N₄O₆S₂
Cas No.	148016-81-3
Smiles	C(O)(=O)C=1N2[C@@]([C@@]([C@@H](C)O)(C2=O)[H])([C@@H](C)C1S[C@H]3C[C@@H](CNS(N)(=O)=O)NC3)[H]
Relative Density.	1.59 g/cm3

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 7.14 mg/mL (16.98 mM), Sonication is recommended.

DMSO: 245 mg/mL (582.64 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (11.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3781 mL	11.8906 mL	23.7812 mL	118.9061 mL
5 mM	0.4756 mL	2.3781 mL	4.7562 mL	23.7812 mL
10 mM	0.2378 mL	1.1891 mL	2.3781 mL	11.8906 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1189 mL	0.5945 mL	1.1891 mL	5.9453 mL
50 mM	0.0476 mL	0.2378 mL	0.4756 mL	2.3781 mL
100 mM	0.0238 mL	0.1189 mL	0.2378 mL	1.1891 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc