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Ditekiren

Catalog No. T25345 CAS 103336-05-6

Synonyms: U 71038, U71038, U-71038, Ditekirenum

Ditekiren is a renin inhibitor with orally active.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ditekiren, CAS 103336-05-6

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25 mg	Inquiry	$ 1,520.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Ditekiren is a renin inhibitor with orally active.

Synonyms	U 71038, U71038, U-71038, Ditekirenum
Molecular Weight	930.19
Formula	C50H75N9O8
CAS No.	103336-05-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Zimmerman BG. Greater blood pressure-lowering effect of the renin inhibitor EMD 58265 than an angiotensin-converting enzyme inhibitor in two-kidney one-clip Goldblatt rabbit. Clin Exp Pharmacol Physiol. 2000 May-Jun;27(5-6):370-7. PubMed PMID: 10831238. 2. Lecureur V, Sun D, Hargrove P, Schuetz EG, Kim RB, Lan LB, Schuetz JD. Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein. Mol Pharmacol. 2000 Jan;57(1):24-35. PubMed PMID: 10617675. 3. Kim RB, Perry PR, Wilkinson GR. High affinity uptake by isolated rat hepatocytes of a linear pseudo-hexapeptide, ditekiren. Biochim Biophys Acta. 1997 Aug 14;1328(1):41-7. PubMed PMID: 9298943. 4. Takahashi H, Kim RB, Perry PR, Wilkinson GR. Characterization of the hepatic canalicular membrane transport of a model oligopeptide: ditekiren. J Pharmacol Exp Ther. 1997 Apr;281(1):297-303. PubMed PMID: 9103510.

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ditekiren 103336-05-6 U 71038 U71038 U-71038 Ditekirenum inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.