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Dipyrithione

Catalog No. T7969 CAS 3696-28-4

Dipyrithione appears to have novel cytotoxicity and potent broad-spectrum antitumor activity

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Dipyrithione, CAS 3696-28-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 53.00
10 mg	In stock	$ 75.00
25 mg	In stock	$ 128.00
50 mg	In stock	$ 192.00
100 mg	In stock	$ 287.00
200 mg	In stock	$ 431.00
500 mg	In stock	$ 713.00
1 mL * 10 mM (in DMSO)	In stock	$ 63.00

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Purity: 99.86%

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Description	Dipyrithione appears to have novel cytotoxicity and potent broad-spectrum antitumor activity
In vitro	Dipyrithione(PTS2) inhibited proliferation in four cancer cell lines in a dose-dependent manner. Treated cells showed shrinkage, irregular fragments, condensed and dispersed blue fluorescent particles compared with control cells. PTS2 induced cycle-arrest and death. Cleavage of caspase-9, caspase-3, and PARP were detected in PTS2-treated cells. Antitumor activity of PTS2 was more effective against widely used cancer drugs and its precursor[1].
Cell Research	Used MTT assays and trypan blue staining to test the viability of cancer cell lines. Hoechst 33258 and DAPI staining were used to observe cell apoptosis. Cell-cycle percentages were analyzed by flow cytometry. Apoptosis was assayed using caspase-3 and poly (ADP-ribose) polymerase (PARP) combined with Western blotting. Student's t-test was used for statistical analysis[1].

Molecular Weight	252.31
Formula	C10H8N2O2S2
CAS No.	3696-28-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.52 mg/mL (10 mM), Sonication is recommended.

References and Literature

1. Fan Y , Liu C , Huang Y , et al. Dipyrithione induces cell-cycle arrest and apoptosis in four cancer cell lines in vitro and inhibits tumor growth in a mouse model[J]. BMC Pharmacology and Toxicology, 2013, 14(1):1-8. 2. Xun, Song, Yuan-Xin, et al. In vivo antifungal activity of dipyrithione against Trichophyton rubrum on guinea pig dermatophytosis models.[J]. Biomedecine & Pharmacotherapie, 2018.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Anti-Cancer Compound Library FDA-Approved & Pharmacopeia Drug Library NO PAINS Compound Library Bioactive Compounds Library Max Approved Drug Library Bioactive Compound Library

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Keywords

Dipyrithione 3696-28-4 Others dermatophytosis G1 phase antiproliferative antifungal Apoptosis Bacterial anti-inflammatory anti-tumor Fungal Inhibitor inhibit inhibitor

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