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Diptoindonesin G

Catalog No. T31523 CAS 1190948-58-3

Diptoindonesin G is an ERß stabilizer that regulates the stability of ERα and ERß by targeting CHIP E3 ubiquitin ligase. Diptoindonesin G could significantly increase the protein stability of ERß, and reduce the protein level of ERα,

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Diptoindonesin G, CAS 1190948-58-3

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	360.32
Formula	C21H12O6
CAS No.	1190948-58-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Xu T, Sun T, Zhang Y, Qiu B, Wang Y, Qin Y, Dong G. RhI-Catalyzed Carboacylation/Aromatization Cascade Initiated by Regioselective C-C Activation of Benzocyclobutenones. Angew Chem Int Ed Engl. 2018 Jan 23. doi: 10.1002/anie.201713179. [Epub ahead of print] PubMed PMID: 29360217. 2. Singh DK, Kim I. Skeletal Reorganization: Synthesis of Diptoindonesin G from Pauciflorol F. J Org Chem. 2018 Jan 24. doi: 10.1021/acs.joc.7b03089. [Epub ahead of print] PubMed PMID: 29322777. 3. Gao J, Fan M, Xiang G, Wang J, Zhang X, Guo W, Wu X, Sun Y, Gu Y, Ge H, Tan R, Qiu H, Shen Y, Xu Q. Diptoindonesin G promotes ERK-mediated nuclear translocation of p-STAT1 (Ser727) and cell differentiation in AML cells. Cell Death Dis. 2017 May 4;8(5):e2765. doi: 10.1038/cddis.2017.159. PubMed PMID: 28471454; PubMed Central PMCID: PMC5520695. 4. Jung Y, Singh DK, Kim I. Symmetry-based approach to oligostilbenoids: Rapid entry to viniferifuran, shoreaphenol, malibatol A, and diptoindonesin G. Beilstein J Org Chem. 2016 Dec 12;12:2689-2693. doi: 10.3762/bjoc.12.266. eCollection 2016. PubMed PMID: 28144340; PubMed Central PMCID: PMC5238531.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Diptoindonesin G 1190948-58-3 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.