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Difluprednate

Catalog No. T6472 CAS 23674-86-4

Synonyms: Myser, Epitopic, CM 9155

Difluprednate (Myser)(Durezol) is a corticosteroid, approved for the treatment of post-operative ocular inflammation and pain.

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Difluprednate, CAS 23674-86-4

Pack Size	Availability	Price/USD
10 mg	In stock	$ 33.00
25 mg	In stock	$ 50.00
50 mg	In stock	$ 73.00
100 mg	In stock	$ 103.00
200 mg	In stock	$ 186.00
500 mg	In stock	$ 297.00
1 mL * 10 mM (in DMSO)	In stock	$ 40.00

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Purity: 99.58%

Purity: 99.23%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Difluprednate (Myser)(Durezol) is a corticosteroid, approved for the treatment of post-operative ocular inflammation and pain.
In vitro	The difluprednate emulsion formulation begin by suspending DFBA in a variety of oils (castor, cottonseed, medium-chain fatty acid triglyceride, oleic, olive, peanut, and soybean). [1] Difluprednate ophthalmic emulsion's active metabolite, 6α,9-difluoroprednisolone 17-butyrate (DFB), has the lowest Ki value (611 nM) for the glucocorticoid receptor and is significantly more active than prednisolone, which has a Ki value of 3.4 nM. [2]
In vivo	Difluprednate emulsion is rapidly deacetylated in the aqueous humor to difluoroprednisolone butyrate (DFB) in rats and rabbits, the drug's active metabolite, which has a similar corticosteroid activity profile. Radio-labeled difluprednate is instilled in the right eyes of pigmented rabbits in a separate study examining DFBA excretion. Difluprednate (0.05% emulsion) results in higher aqueous humor concentrations than the suspension form in the eyes of rabbits. Difluprednate concentrations ≥0.01% shows a statistically significant inhibition of inflammation compared to saline in a rabbit model, with the anti-inflammatory response proceeding in a dose-dependent manner. Difluprednate suppresses uveitis in all three concentration (0.002%, 0.01%, and 0.05%) in a dose-dependent manner in rats, and difluprednate 0.05% shows statistically superior anti-inflammatory activity compared to Betamethasone (0.1%). [1]

Synonyms	Myser, Epitopic, CM 9155
Molecular Weight	508.55
Formula	C27H34F2O7
CAS No.	23674-86-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 24 mg/mL (47.2 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 93 mg/mL (182.9 mM)

References and Literature

1. Jamal KN, et al. Clin Ophthalmol, 2009, 3, 381-390. 2. Donnenfeld ED, et al. Clin Ophthalmol, 2011, 5, 811-816.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Pediatric Drug Library FDA-Approved & Pharmacopeia Drug Library ReFRAME Related Library Clinical Compound Library Bioactive Compound Library FDA-Approved Drug Library Human Metabolite Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Difluprednate 23674-86-4 Others Myser Epitopic inhibit Phospholipase CM9155 Inhibitor CM 9155 CM-9155 inhibitor

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