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Desferrithiocin

Catalog No. T31387 CAS 105635-69-6

Synonyms: DFT

Desferrithiocin is a more active iron chelator than desferrioxamine.

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Desferrithiocin, CAS 105635-69-6

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25 mg	Inquiry	$ 1,520.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Desferrithiocin is a more active iron chelator than desferrioxamine.

Synonyms	DFT
Molecular Weight	238.26
Formula	C10H10N2O3S
CAS No.	105635-69-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Taher AT, Saliba AN, Kuo KH, Giardina PJ, Cohen AR, Neufeld EJ, Aydinok Y, Kwiatkowski JL, Jeglinski BI, Pietropaolo K, Berk G, Viprakasit V. Safety and pharmacokinetics of the oral iron chelator SP-420 in β-thalassemia. Am J Hematol. 2017 Dec;92(12):1356-1361. doi: 10.1002/ajh.24914. Epub 2017 Oct 31. PubMed PMID: 28940308. 2. Kaviani S, Izadyar M, Housaindokht MR. A DFT study on the complex formation between desferrithiocin and metal ions (Mg(2+), Al(3+), Ca(2+), Mn(2+), Fe(3+), Co(2+), Ni(2+), Cu(2+), Zn(2+)). Comput Biol Chem. 2017 Apr;67:114-121. doi: 10.1016/j.compbiolchem.2016.12.012. Epub 2017 Jan 3. PubMed PMID: 28068516. 3. Bergeron RJ, Bharti N, McManis JS, Wiegand J. Metabolically programmed iron chelators. Bioorg Med Chem. 2015 Sep 1;23(17):5954-71. doi: 10.1016/j.bmc.2015.06.059. Epub 2015 Jun 29. PubMed PMID: 26231739; PubMed Central PMCID: PMC4608554. 4. Hider RC, Kong X, Abbate V, Harland R, Conlon K, Luker T. Deferitazole, a new orally active iron chelator. Dalton Trans. 2015 Mar 21;44(11):5197-204. doi: 10.1039/c5dt00063g. PubMed PMID: 25687725.

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Desferrithiocin 105635-69-6 DFT inhibitor inhibit

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