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Davunetide

Catalog No. T21470 CAS 211439-12-2

Synonyms: AL-208, AL 208, AL 108, AL-108

Davunetide is an eight amino acid peptide (NAPVSIPQ) with potent neuroprotection in vitro and in vivo. Davunetide has been shown to enhance functional daily behaviors in schizophrenia patients and to increase memory scores in patients suffering from amnestic mild cognitive impairment.

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Davunetide, CAS 211439-12-2

Pack Size	Availability	Price/USD	Quantity
1 mg	35 days	$ 198.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	AL-208, AL 208, AL 108, AL-108
Molecular Weight	824.92
Formula	C36H60N10O12
CAS No.	211439-12-2

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

H2O: Insoluble

References and Literature

1. Arya A, Meena R, Sethy NK, Das M, Sharma M, Bhargava K. NAP (davunetide) protects primary hippocampus culture by modulating expression profile of antioxidant genes during limiting oxygen conditions. Free Radic Res. 2015 Apr;49(4):440-52. doi: 10.3109/10715762.2015.1011153. Epub 2015 Mar 2. PubMed PMID: 25727410. 2. Magen I, Ostritsky R, Richter F, Zhu C, Fleming SM, Lemesre V, Stewart AJ, Morimoto BH, Gozes I, Chesselet MF. Intranasal NAP (davunetide) decreases tau hyperphosphorylation and moderately improves behavioral deficits in mice overexpressing α-synuclein. Pharmacol Res Perspect. 2014 Oct;2(5):e00065. doi: 10.1002/prp2.65. Epub 2014 Aug 6. PubMed PMID: 25505609; PubMed Central PMCID: PMC4186425. 3. Sethy NK, Sharma NK, Das M, Bhargava K. Protein profiling reveals antioxidant and signaling activities of NAP (Davunetide) in rodent hippocampus exposed to hypobaric hypoxia. J Mol Neurosci. 2014 Nov;54(3):414-29. doi: 10.1007/s12031-014-0381-9. Epub 2014 Jul 20. PubMed PMID: 25038875. 4. Boxer AL, Lang AE, Grossman M, Knopman DS, Miller BL, Schneider LS, Doody RS, Lees A, Golbe LI, Williams DR, Corvol JC, Ludolph A, Burn D, Lorenzl S, Litvan I, Roberson ED, Höglinger GU, Koestler M, Jack CR Jr, Van Deerlin V, Randolph C, Lobach IV, Heuer HW, Gozes I, Parker L, Whitaker S, Hirman J, Stewart AJ, Gold M, Morimoto BH; AL-108-231 Investigators. Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial. Lancet Neurol. 2014 Jul;13(7):676-85. doi: 10.1016/S1474-4422(14)70088-2. Epub 2014 May 27. PubMed PMID: 24873720; PubMed Central PMCID: PMC4129545.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Davunetide 211439-12-2 AL-208 AL 208 AL 108 AL108 AL-108 AL208 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.