Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Potent and selective GPR84 biased agonist (EC50 = 33 nM). Exhibits no significant activity in a panel of 168 other GPCRs. Exhibits bias for G protein signaling pathways. Induces morphological changes in primary murine bone marrow-derived macrophages (BMDMs) in a cellular impedance assay, and promotes phagocytosis by M1 polarized U937 cells. Induces migration of primary human monocytes, but has no effect on macrophage chemotaxis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | Inquiry | $ 1,289.00 | |
50 mg | Inquiry | $ 1,980.00 |
Description | Potent and selective GPR84 biased agonist (EC50 = 33 nM). Exhibits no significant activity in a panel of 168 other GPCRs. Exhibits bias for G protein signaling pathways. Induces morphological changes in primary murine bone marrow-derived macrophages (BMDMs) in a cellular impedance assay, and promotes phagocytosis by M1 polarized U937 cells. Induces migration of primary human monocytes, but has no effect on macrophage chemotaxis. |
Molecular Weight | 299.75 |
Formula | C17H14ClNO2 |
CAS No. | 2487253-25-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 29.98 mg/mL(100 mM)
Ethanol: 29.98 mg/mL(100 mM)
You can also refer to dose conversion for different animals. More
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DL 175 2487253-25-6 DL175 DL-175 inhibitor inhibit