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DCC-2036

Catalog No. T2640    CAS 1020172-07-9    Synonyms: DCC2036, DCC 2036, Rebastinib

DCC-2036 (Rebastinib) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC, HCK, FGR, FLT3, KDR, and Tie-2, and low activity to c-Kit.

Pack Size Availability Price/USD Quantity
2 mg In stock 56.00
5 mg In stock 100.00
10 mg In stock 168.00
25 mg In stock 302.00
50 mg In stock 450.00
1 mL * 10 mM (in DMSO) In stock 130.00
Bulk Size: Please Quote for Discount Please Quote for Bulk Size
Biological Activity:

Product Description:

DCC-2036 (Rebastinib) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC, HCK, FGR, FLT3, KDR, and Tie-2, and low activity to c-Kit.

Receptor:

Abl1; FLT3; p-Abl1 (native); p-Abl1 (T315I); u-Abl1 (native);

Chemical Information:
Molecular Weight 553.59
Formula C30H28FN7O3
CAS Number 1020172-07-9
Solubility

DMSO: 103 mg/mL (186.1 mM)

Ethanol: 13 mg/mL (23.5 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage store at -80°C
Remark For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month.
Technical Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Reference
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