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Cyclo-(Pro-Gly)

Catalog No. TN6674 CAS 19179-12-5

Synonyms: Cyclo(Pro-Gly)

Cyclo(Pro-Gly) is an active metabolite of piracetam-N-phenylacetyl-L-prolylglycine (GWS-111), it shows a greater resistance to an enzymatic effect than natural neuropeptides. Cyclo-(Gly-Pro) shows cytotoxicity at the concentration of 10 umol/L, it inhibits the growth of Bacillus subtilis with the minimal inhibitory concentration (MIC) value of 0.8, 0.8 g/L.

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Cyclo-(Pro-Gly), CAS 19179-12-5

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Description

In vitro

METHODS AND RESULTS:In the present study, an endophytic fungus isolate FTJZZJ09, which isolated from the fresh bulbs of Fritillaria thunbergii Miq., was identified as Penicillium chrysogenum based on its morphological characters and internal transcribed spacer (ITS) sequence. After being cultured in the modified CzapeK-DoX medium (3 g/L maltose, 3 g/L peptone A, 0.1 g/L K2HPO4, 0.05 g/L KCl, 0.3 g/L NaNO3, 0.05 g/L MgSO4·7H2O, 0.001 g/L FeSO4·7H2O, pH 6.5), it can secrete antibacterial metabolites under the condition of 28 °C in a rotary shaker at 160 r/min for 7 days. Three antibacterial compounds were isolated from the ethyl acetate extract of the fermentation broth by silica gel, they were elucidated as Cyclo(Pro-Gly) , cyclo (Pro-Val) and 2-acetyl-4 (3H) quinazolinone. CONCLUSIONS: All the three compounds could inhibit the growth of Bacillus subtilis with the minimal inhibitory concentration (MIC) value of 0.8, 0.8, and 0.4 g/L respectively, while they showed no apparent effects against the growth of Gram-negative bacteria.

Synonyms	Cyclo(Pro-Gly)
Molecular Weight	154.1665
Formula	C7H10N2O2
CAS No.	19179-12-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. The Endophytic Fungus Strain FTJZZJ09 Isolated from the Bulbs of Fritillaria thunbergii and Its Antibacterial Metabolites Microbiology China,2010, 37(10):1475-80.

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Keywords

Cyclo-(Pro-Gly) 19179-12-5 Cyclo (Pro Gly) Cyclo(Pro-Gly) Cyclo(ProGly) inhibitor inhibit

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