Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cyclo(Phe-Gly) shows weak antagonistic activity against VEGFR2 -CD, it also shows strong inhibitory activity against human cancer cells(KB,KBv200) with LD50 at 6.5 and 11.2 umol/L,respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | Inquiry | $ 730.00 | |
1 mL * 10 mM (in DMSO) | Inquiry | $ 500.00 |
Description | Cyclo(Phe-Gly) shows weak antagonistic activity against VEGFR2 -CD, it also shows strong inhibitory activity against human cancer cells(KB,KBv200) with LD50 at 6.5 and 11.2 umol/L,respectively. |
In vitro | To discover antagonists of VEGFR2-CD from the fermentation broth produced by streptomyces strain I06A-02832. METHODS AND RESULTS:Under the guidance of ELISA assay against VEGFR2-CD, Compounds 2832 B and 2832 C were isolated and purified by combination of different column chromatographies and HPLC. The structures of compounds 2832 B and C were identified by combination of analysis of UV, IR, MS and 1D-NMR, 2D-NMR. Compounds 2832 B and 2832 C were purified and structurally identified as cyclic dipeptides, and were the same with cyclo-(Pro-Tyr) and Cyclo(Phe-Gly) respectively. Compounds 2832 B and 2832 C showed weak antagonistic activity against VEGFR2-CD by ELISA assay. CONCLUSIONS: They are firstly reported compounds 2832 B and 2832 C had antagonistic activity against VEGFR2-CD. |
Molecular Weight | 204.23 |
Formula | C11H12N2O2 |
CAS No. | 5037-75-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Cyclo(Phe-Gly) 5037-75-2 Cyclo(Phe Gly) Cyclo(PheGly) inhibitor inhibit