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Cort108297

Name: Cort108297
Brand: TargetMol
SKU: T15000
Price: 289 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15000 Copy Product Info

Purity: 99.94%

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Cort108297 is a selective glucocorticoid receptor modulator and a selective GR antagonist with no affinity for other steroid receptors. Cort108297 showed a high affinity for GRs (Ki: 0.45nM).

Cas No. 1018679-79-2

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Pack Size	Price	USA Stock	Global Stock
1 mg	$289	In Stock	In Stock
5 mg	$655	In Stock	In Stock
10 mg	$955	In Stock	In Stock
25 mg	$1,490	In Stock	In Stock
50 mg	$1,980	In Stock	In Stock
100 mg	$2,890	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$787	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.94%

ee:100%

Appearance:Solid

Color:White to Purple

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COA CSFC HNMR LCMS ORP

Product Introduction

Bioactivity

Description	Cort108297 is a selective glucocorticoid receptor modulator and a selective GR antagonist with no affinity for other steroid receptors. Cort108297 showed a high affinity for GRs (Ki: 0.45nM).
Targets & IC50	GR:（ki）0.45 nM
In vitro	Cort108297 and CORT118335 had antagonistic effects on dexamethasone-induced KLK3 expression, which were 48% (p<0.05) and 60% (p<0.05), respectively. CORT118335(1µM) inhibited dexamethasone-induced SGK1 expression by 50%. However, Cort108297 was able to completely inhibit dexamethasone-mediated SGK1 elevation (p<0.05). After 3 days of dexamethasone ±SGRMs treatment in CWR-22RV1 cells, the induction effect of SGK1 gene expression was 100 times greater than that in re treated cells, while Cort108297 and CORT118335 completely inhibited this effect (p<0.01). Cort108297 and CORT118335 inhibited 70% and 75% of induction effects, respectively (p<0.01)[1].
In vivo	At the end of the treatment period, mice treated with Cort108297(40 mg/kg BID) or Cort108297 (80 mg/kg QD) also have significantly lower steady plasma glucose than mice receiving vehicle[3]. Male rats are treated for five days with Mifepristone (10 mg/kg), Cort108297 (30 mg/kg and 60 mg/kg), Imipramine (10mg/kg) or vehicle and exposed to forced swim test (FST) or restraint stress. Experimental data showed that both doses of Cort108297 can effectively inhibit corticosterone response to FST and restraint stress, while only high dose of Cort108297 (60mg/kg) can significantly reduce immobility in forced swimming test (FST). [1].

Chemical Properties

Molecular Weight	535.55
Formula	C₂₆H₂₅F₄N₃O₃S
Cas No.	1018679-79-2
Smiles	CCOC[C@@]12CN(CCC1=Cc1c(C2)cnn1-c1ccc(F)cc1)S(=O)(=O)c1ccc(cc1)C(F)(F)F
Relative Density.	1.40 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (102.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: < 5.5 mg/mL (10.27 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5.5 mg/mL (10.27 mM), Suspension.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8672 mL	9.3362 mL	18.6724 mL	93.3620 mL
5 mM	0.3734 mL	1.8672 mL	3.7345 mL	18.6724 mL
10 mM	0.1867 mL	0.9336 mL	1.8672 mL	9.3362 mL
20 mM	0.0934 mL	0.4668 mL	0.9336 mL	4.6681 mL
50 mM	0.0373 mL	0.1867 mL	0.3734 mL	1.8672 mL
100 mM	0.0187 mL	0.0934 mL	0.1867 mL	0.9336 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc