Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM). In this way, it blocks the acidification of vacuolar organelles as well as early to late endosomal transport. Concanamycin B interferes with bone resorption and maturation of CD8 T lymphocytes. It also prevents processing of major histocompatibility complex (MHC) class II precursors in human B cells, inhibiting the expression of MHC class II molecules on the cell surface.
Pack Size | Availability | Price/USD | Quantity |
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1 mg | Inquiry | $ 1,895.00 |
Description | Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM). In this way, it blocks the acidification of vacuolar organelles as well as early to late endosomal transport. Concanamycin B interferes with bone resorption and maturation of CD8 T lymphocytes. It also prevents processing of major histocompatibility complex (MHC) class II precursors in human B cells, inhibiting the expression of MHC class II molecules on the cell surface. |
Molecular Weight | 852.072 |
Formula | C45H73NO14 |
CAS No. | 81552-33-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
DMF: Soluble
Ethanol: Soluble
Methanol: Soluble
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Concanamycin B 81552-33-2 inhibitor inhibit