Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Clobutinol has anti-tussive effects. Clobutinol affects heart rate and blood pressure, it can be used for cough related research [1] [2] [3].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Clobutinol has anti-tussive effects. Clobutinol affects heart rate and blood pressure, it can be used for cough related research [1] [2] [3]. |
In vitro | Clobutinol markedly suppresses the voltage-gated outward current in cells expressing hERG at a concentration of 10 μM [1]. Furthermore, in hERG transfected cells, clobutinol (0-1000 μM) inhibits this outward current, demonstrating an IC 50 value of 1.9 μM [1]. |
In vivo | Clobutinol, administered intravenously at doses ranging from 1-20 mg/kg, was found to have no significant impact on the airways of anesthetized guinea pigs. However, at doses of 1 and 10 mg/kg, clobutinol influenced the cardiovascular system, notably decreasing heart rate and mean blood pressure in anesthetized closed-chest guinea pigs. This effect was more pronounced with the higher dosage of 10 mg/kg, indicating a dose-dependent response on cardiovascular parameters without affecting the respiratory system. |
Molecular Weight | 255.78 |
Formula | C14H22ClNO |
CAS No. | 14860-49-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Clobutinol 14860-49-2 inhibitor inhibit