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Cirsimarin

Name: Cirsimarin
Brand: TargetMol
SKU: T10822
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10822Cas No. 13020-19-4

Alias Cirsitakaoside

Cirsimarin (Cirsitakaoside) is a flavonoid isolated from Microtea debilis. It shows a potent antilipogenic effect and decreases adipose tissue deposition in mice. Cirsimarin has antagonist activity on the adenosine A1 receptor and inhibitory effect on phosphodiesterase.

Cirsimarin

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Purity: 99.01%

Catalog No. T10822Alias CirsitakaosideCas No. 13020-19-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	-	In Stock
5 mg	$153	-	In Stock
10 mg	$251	-	In Stock
25 mg	$412	-	In Stock
50 mg	$573	-	In Stock
100 mg	$768	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.01%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Cirsimarin AI Summary

Cirsimarin exhibits multiple bioactivities. It shows an inhibition of 12.2% on cow milk xanthine oxidase at a concentration of 50 µg/mL and demonstrates an inhibition of xanthine oxidase, which leads to a decrease in uric acid production, with an IC50 value greater than 100000.0 nM. Additionally, it has antioxidant activity, demonstrated through superoxide-scavenging activity using the nitrite method, with an IC50 value greater than 100000.0 nM. In terms of its action on the adenosine A1 receptor, Cirsimarin acts as an antagonist, displaying 2.0% activity in displacing [3H]DPCPX from the receptor in rat forebrain membrane at 100 µg/mL concentration and has a Ki value of 3200.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cirsimarin (Cirsitakaoside) is a flavonoid isolated from Microtea debilis. It shows a potent antilipogenic effect and decreases adipose tissue deposition in mice. Cirsimarin has antagonist activity on the adenosine A1 receptor and inhibitory effect on phosphodiesterase.
Synonyms	Cirsitakaoside

Chemical Properties

Molecular Weight	476.43
Formula	C₂₃H₂₄O₁₁
Cas No.	13020-19-4
Smiles	COc1cc2oc(cc(=O)c2c(O)c1OC)-c1ccc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Relative Density.	1.523g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.33 mg/mL (174.91 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0989 mL	10.4947 mL	20.9894 mL	104.9472 mL
5 mM	0.4198 mL	2.0989 mL	4.1979 mL	20.9894 mL
10 mM	0.2099 mL	1.0495 mL	2.0989 mL	10.4947 mL
20 mM	0.1049 mL	0.5247 mL	1.0495 mL	5.2474 mL
50 mM	0.0420 mL	0.2099 mL	0.4198 mL	2.0989 mL
100 mM	0.0210 mL	0.1049 mL	0.2099 mL	1.0495 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc