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Chrysophanol

Chrysophanol
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Purity:99.7%
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Chrysophanol

Catalog No. T2995Cas No. 481-74-3
Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.
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Pack SizePriceAvailabilityQuantity
50 mg$32In Stock
100 mg$48In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Product Introduction

Bioactivity
Description
Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.
In vivo
Chrysophanol (CA) has been shown to counteract obesity in C57BL/6 mice induced by a high-fat diet (HFD). Through in vivo studies involving male C57BL/6J mice, it was discovered that Chrysophanol significantly mitigates weight gain associated with HFD consumption. Specifically, mice subsisting on an HFD without Chrysophanol treatment experienced a weight increase of 23.92 ± 1.74 g over 16 weeks. In contrast, mice treated with Chrysophanol exhibited a markedly lower weight gain of 16.72 ± 2 g in the same period, underscoring Chrysophanol's potential as an effective intervention against HFD-induced obesity.
Cell Research
Chrysophanol (Chrysophanic Acid) is dissolved in DMSO and stored, and then diluted with appropriate medium before use[1]. The cells are seeded at 5×103 cells/mL in 96-well microplates and allowed to attach for 24 h. Chrysophanol (20, 50, 80 and 120 μM) is added to the medium at various concentrations up to 120 μM and for different durations. After treatment, cell cytotoxicity and/or proliferation is assessed by a Cell Counting Kit-8 (CCK-8). Briefly, highly water-soluble tetrazolium salt, WST-8, produces an orange colored water-soluble product, formazan. The amount of formazan dye generated by dehydrogenases in cells is directly proportional to the number of living cells.CCK-8 (10 μL) is added to each well and incubated for 3 h at 37°C, then cell proliferation and cytotoxicity are assessed by measuring the absorbance at 450 nm using a microplate reader.Three replicated wells are used for each experimental condition[1].
Alias3-Methylchrysazin, Chrysophanic Acid, Turkey Rhubarb
Chemical Properties
Molecular Weight254.24
FormulaC15H10O4
Cas No.481-74-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 1mg/ml

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