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Chaetominine

Catalog No. T30869 CAS 918659-56-0

Synonyms: NSC 746369, NSC-746369, NSC746369

Chaetominine is a type of cytotoxic alkaloid obtained from endophytic Chaetomium sp. IFB-E015.

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Chaetominine, CAS 918659-56-0

Pack Size	Availability	Price/USD	Quantity
5 mg	Inquiry	$ 2,604.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Chaetominine is a type of cytotoxic alkaloid obtained from endophytic Chaetomium sp. IFB-E015.

Synonyms	NSC 746369, NSC-746369, NSC746369
Molecular Weight	402.4
Formula	C22H18N4O4
CAS No.	918659-56-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Liu CQ, Pan ZH, An FL, Lu YH. Co-addition Strategy for Enhancement of Chaetominine from Submerged Fermentation of Aspergillus fumigatus CY018. Appl Biochem Biotechnol. 2018 Apr 10. doi: 10.1007/s12010-018-2714-6. [Epub ahead of print] PubMed PMID: 29637396. 2. Zhou Y, Breit B. Rhodium-Catalyzed Asymmetric N-H Functionalization of Quinazolinones with Allenes and Allylic Carbonates: The First Enantioselective Formal Total Synthesis of (-)-Chaetominine. Chemistry. 2017 Dec 22;23(72):18156-18160. doi: 10.1002/chem.201705059. Epub 2017 Dec 5. PubMed PMID: 29105185. 3. Yao J, Wei X, Lu Y. Chaetominine reduces MRP1-mediated drug resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells. Biochem Biophys Res Commun. 2016 May 13;473(4):867-873. doi: 10.1016/j.bbrc.2016.03.141. Epub 2016 Mar 30. PubMed PMID: 27038543. 4. Liu C, Jiao R, Yao L, Zhang Y, Lu Y, Tan R. Adsorption characteristics and preparative separation of chaetominine from Aspergillus fumigatus mycelia by macroporous resin. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Mar 15;1015-1016:135-141. doi: 10.1016/j.jchromb.2016.02.027. Epub 2016 Feb 20. PubMed PMID: 26919448.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Chaetominine 918659-56-0 NSC 746369 NSC-746369 NSC746369 inhibitor inhibit

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