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Cefotetan disodium

Catalog No. T21400 CAS 74356-00-6

Synonyms: YM09330, YM-09330, ICI-156834, ICI 156834, YM 09330, Cefotetan Sodium, ICI156834

Cefotetan Sodium, a second-generation cephalosporin, cephamycin antibiotic, is active against a wide range of both aerobic and anaerobic gram-negative and gram-positive bacteria. Cefotetan disrupts the cell wall synthesis by binding to penicillin-binding proteins.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Cefotetan disodium, CAS 74356-00-6

Pack Size	Availability	Price/USD
50 mg	35 days	$ 160.00
100 mg	35 days	$ 253.00
250 mg	35 days	$ 590.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	YM09330, YM-09330, ICI-156834, ICI 156834, YM 09330, Cefotetan Sodium, ICI156834
Molecular Weight	619.57
Formula	C17H15N7Na2O8S4
CAS No.	74356-00-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

H2O: Insoluble

References and Literature

1. Nam YH, Hwang EK, Ban GY, Jin HJ, Yoo HS, Shin YS, Ye YM, Nahm DH, Park HS, Lee SK. Immunologic evaluation of patients with cefotetan-induced anaphylaxis. Allergy Asthma Immunol Res. 2015 May;7(3):301-3. doi: 10.4168/aair.2015.7.3.301. PubMed PMID: 25749763; PubMed Central PMCID: PMC4397372. 2. Liu Y, Huang J, Liu J, Ma L, Lv Y, Shi S. A simple and sensitive liquid chromatographic technique for the determination of cefotetan disodium in human plasma and its application in a pharmacokinetic study. J Huazhong Univ Sci Technolog Med Sci. 2012 Oct;32(5):779-84. doi: 10.1007/s11596-012-1034-2. PubMed PMID: 23073813. 3. Su MX, Liu MH, Di B, Huang LL, Jiang Y, Ma PC, Hang TJ. Pharmacokinetic differences between the epimers of cefotetan disodium after single intravenous injection in healthy Chinese volunteers. Eur J Drug Metab Pharmacokinet. 2011 Dec;36(4):223-8. doi: 10.1007/s13318-011-0064-7. PubMed PMID: 21915733. 4. Shi S, Liu Y, Li Z, Zheng H, Lv Y, Chen H. Pharmacokinetics and tolerability of intravenous cefotetan disodium for injection in healthy Chinese volunteers: A randomized, open-label, single- and multiple-dose study. Clin Ther. 2010 Sep;32(10):1832-41. doi: 10.1016/j.clinthera.2010.09.015. PubMed PMID: 21194607.

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

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Step Two: Enter the in vivo formulation

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

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Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

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Concentration (End)

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Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Desired Reconstitution Concentration

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Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Cefotetan disodium 74356-00-6 Cefotetan YM09330 YM-09330 ICI-156834 ICI 156834 YM 09330 Cefotetan Sodium ICI156834 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.