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Captopril disulfide

Catalog No. T20512 CAS 64806-05-9

Synonyms: SQ14,551, SQ 14,551, SQ-14,551

Captopril disulfide, a metabolite of Captopril, is a new antihypertensive agent.

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Captopril disulfide, CAS 64806-05-9

Pack Size	Availability	Price/USD
5 mg	35 days	$ 296.00
10 mg	35 days	$ 575.00
25 mg	35 days	$ 1,280.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Captopril disulfide, a metabolite of Captopril, is a new antihypertensive agent.

Synonyms	SQ14,551, SQ 14,551, SQ-14,551
Molecular Weight	432.56
Formula	C18H28N2O6S2
CAS No.	64806-05-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Bojarska J, Maniukiewicz W, Fruziński A, Sieroń L, Remko M. Captopril and its dimer captopril disulfide: comparative structural and conformational studies. Acta Crystallogr C Struct Chem. 2015 Mar;71(Pt 3):199-203. doi: 10.1107/S2053229615002582. Epub 2015 Feb 18. PubMed PMID: 25734850. 2. Mahmoud WM, Kümmerer K. Captopril and its dimer captopril disulfide: photodegradation, aerobic biodegradation and identification of transformation products by HPLC-UV and LC-ion trap-MS(n). Chemosphere. 2012 Aug;88(10):1170-7. doi: 10.1016/j.chemosphere.2012.03.064. Epub 2012 Apr 24. PubMed PMID: 22534199. 3. Drummer OH, Jarrott B. Captopril disulfide conjugates may act as prodrugs: disposition of the disulfide dimer of captopril in the rat. Biochem Pharmacol. 1984 Nov 15;33(22):3567-71. PubMed PMID: 6095854. 4. Bathala MS, Weinstein SH, Meeker FS Jr, Singhvi SM, Migdalof BH. Quantitative determination of captopril in blood and captopril and its disulfide metabolites in plasma by gas chromatography. J Pharm Sci. 1984 Mar;73(3):340-4. PubMed PMID: 6371216.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Captopril disulfide 64806-05-9 SQ14,551 Captopril Disulfide SQ 14,551 Captopril SQ-14,551 inhibitor inhibit

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