Home Tools

Cantrixil

Catalog No. T39586 CAS 2135511-22-5

Synonyms: TRX-E-002-1

Cantrixil (TRX-E-002-1) is a second-generation super-benzopyran (SBP) compound, derived from TRX-E-002. It elicits an increase in phosphorylated c-Jun levels, leading to caspase-mediated apoptosis in ovarian cancer cells. Cantrixil exhibits potent pan anti-cancer activity against various cancer phenotypes.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Cantrixil, CAS 2135511-22-5

Please contact us for prices and availability for the specification of product you are interested at.
Product consultation

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cantrixil (TRX-E-002-1) is a second-generation super-benzopyran (SBP) compound, derived from TRX-E-002. It elicits an increase in phosphorylated c-Jun levels, leading to caspase-mediated apoptosis in ovarian cancer cells. Cantrixil exhibits potent pan anti-cancer activity against various cancer phenotypes.
In vitro	TRX-E-002-1 exhibits extensive cytotoxic effects against ovarian, prostate, and lung cancer cell lines, demonstrating potent IC 50 values (SK-OV-3, JAM, OVCAR-3: 0.023-0.065 μM; DU145, PC3, C4-2B: 0.014-0.096 μM; A549: 0.058 μM). However, its effectiveness varies more in pancreatic, colorectal cancer, and glioblastoma cells[1]. As Cantrixil, at a concentration of 0.2 μM over 2-24 hours, it significantly increases phosphorylated c-Jun (p-c-Jun) levels while decreasing phosphorylated-ERK (p-ERK) levels[2]. Furthermore, at 2.45 μM for the same duration, Cantrixil substantially elevates caspase-3/7 and caspase-9 activities, particularly after 16 and 24 hours[2]. TRX-E-002-1 also inhibits a range of cytochrome P450 enzymes critical for drug metabolism (CYP2C9, CYP2C8, CYP2C19, CYP2B6, CYP3A4, CYP2D6, CYP2A6, CYP1A2), with IC 50 values spanning 1.5 to 75 μM (612-30,600 ng/mL)[1]. Western blot analysis on ovarian cancer stem cells (OCSCs) treated with 0.2 μM Cantrixil for 2-24 hours indicates increased p-c-Jun and decreased p-ERK levels, alongside a time-dependent rise in both total and phosphorylated c-Jun[2].
In vivo	TRX-E-002-1 administered intraperitoneally (IP) at a dose of 100 mg/kg/day significantly suppresses tumor growth and reduces terminal tumor burden across several mouse models of cancer. In the disseminated ovarian cancer model, treatment for 13-14 days inhibited tumor growth. In the recurrent ovarian cancer model, a 4-week treatment regimen decreased tumor growth, reducing the terminal tumor burden by 77%. When administered for 18 days, TRX-E-002-1 notably decreased the terminal pancreatic tumor burden in a model using human Panc-1 pancreatic tumor cells implanted orthotopically in female NOD-SCID mice. Additionally, pharmacokinetic analysis in both male and female Sprague-Dawley rats revealed a half-life (T 1/2) of 2.5 hours, a peak concentration (C max) of 8355 ng/mL, and an area under the curve (AUC 0-∞) of 40600 ng?h/mL. In the disseminated ovarian cancer mouse model, a similar dosage led to a significant reduction in tumor growth and a 50-72% decrease in excised tumor weight at study's end.

Synonyms	TRX-E-002-1
Molecular Weight	408.45
Formula	C24H24O6
CAS No.	2135511-22-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Muhammad Wasif Saif, et al. Pharmacology and toxicology of the novel investigational agent Cantrixil (TRX-E-002-1). Cancer Chemother Pharmacol. 2017 Feb;79(2):303-314. 2. Ayesha B Alvero, et al. TRX-E-002-1 Induces c-Jun-Dependent Apoptosis in Ovarian Cancer Stem Cells and Prevents Recurrence In Vivo. Mol Cancer Ther. 2016 Jun;15(6):1279-90.

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Cantrixil 2135511-22-5 TRX-E-002-1 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.