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CTCE 9908 acetate

Catalog No. TP2051L

CTCE 9908 acetate is an antagonist of CXCR4 and inhibits migration in CXCR4-expressing ovarian cancer cells.

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CTCE 9908 acetate Chemical Structure
CTCE 9908 acetate, CAS N/A
Pack Size Availability Price/USD Quantity
1 mg In stock $ 257.00
2 mg In stock $ 411.00
5 mg In stock $ 626.00
10 mg In stock $ 939.00
25 mg In stock $ 1,380.00
50 mg In stock $ 1,890.00
100 mg In stock $ 2,550.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CTCE 9908 acetate is an antagonist of CXCR4 and inhibits migration in CXCR4-expressing ovarian cancer cells.
In vitro CTCE 9908 acetate inhibited ovarian cancer cell migration to CXCL12, but on longer incubation, caused cell death in CXCR4-positive cells. CTCE 9908 acetate did not cause apoptosis or cellular senescence, but induced multinucleation, G(2)-M arrest, and abnormal mitosis in ovarian cancer cells. CTCE 9908 acetate deregulated DNA damage checkpoint proteins and spindle assembly checkpoint proteins at G(2)-M phases of the cell cycle. Combination treatment of CTCE 9908 acetate and the drug paclitaxel led to an additive cytotoxicity that also involved mitotic catastrophe[1].
In vivo In dosing experiment of CTCE 9908 acetate in the PyMT mouse model, increasing doses of CTCE 9908 acetate alone slowed the rate of tumor growth, with a 45% inhibition of primary tumor growth at 3.5 weeks of treatment with 50 mg/kg of CTCE 9908 acetate (p = 0.005). Expression levels of VEGF were also found to be reduced by 42% with CTCE 9908 acetate (p = 0.01). In combination with docetaxel, CTCE 9908 acetate administration decreased tumor volume by 38% (p = 0.02), an effect that was greater than that observed with docetaxel alone. In combination with DC101, CTCE 9908 acetate also demonstrated an enhanced effect compared to DC101 alone, with a 37% decrease in primary tumor volume (p = 0.01) and a 75% reduction in distant metastasis (p = 0.009). In combination with docetaxel or an anti-angiogenic agent, the anti-tumor and anti-metastatic effects of CTCE 9908 acetate were markedly enhanced[2].
Molecular Weight 1987.31
Formula C88H151N27O25

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Bioactive Compound Library Anti-Cancer Compound Library Peptide Compound Library Bioactive Compounds Library Max Inhibitor Library Autophagy Compound Library Immunology/Inflammation Compound Library GPCR Compound Library Anti-Ovarian Cancer Compound Library

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Keywords

CTCE 9908 acetate Autophagy GPCR/G Protein Immunology/Inflammation CXCR CTCE 9908 Acetate CTCE-9908 Acetate CTCE9908 Acetate inhibitor inhibit

 

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