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CO23

Name: CO23
Brand: TargetMol
SKU: T10855
Price: 233 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T10855Cas No. 1370363-74-8

CO23 is a blood-brain barrier penetrant and selective TRα agonist and can be used in studies about the regulation of growth and development.

CO23

🥰Excellent

Purity: 98.08%

Catalog No. T10855Cas No. 1370363-74-8

CO23 is a blood-brain barrier penetrant and selective TRα agonist and can be used in studies about the regulation of growth and development.

Pack Size	Price	Availability
1 mg	$233	In Stock
5 mg	$579	In Stock
10 mg	$868	In Stock
25 mg	$1,430	In Stock
50 mg	$1,930	In Stock
100 mg	$2,590	In Stock

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Batch Information

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Purity:98.08%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	CO23 is a blood-brain barrier penetrant and selective TRα agonist and can be used in studies about the regulation of growth and development.
In vivo	Intraperitoneal injection of CO23 (0.8-5.0 nmol/g) reduces about 50% of cholesterol. CO23(0.8, 2.5, and 5 nmol/g) increases Dio1 mRNA 5-, 10-, and 15-fold, respectively[1].

Chemical Properties

Molecular Weight	592.17
Formula	C₁₉H₁₈I₂N₂O₄
Cas No.	1370363-74-8
Smiles	CC(C)c1cc(Oc2c(I)cc(CC3NC(=O)NC3=O)cc2I)ccc1O
Relative Density.	1.878 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225.0 mg/mL (380.0 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6887 mL	8.4435 mL	16.8870 mL	84.4352 mL
5 mM	0.3377 mL	1.6887 mL	3.3774 mL	16.8870 mL
10 mM	0.1689 mL	0.8444 mL	1.6887 mL	8.4435 mL
20 mM	0.0844 mL	0.4222 mL	0.8444 mL	4.2218 mL
50 mM	0.0338 mL	0.1689 mL	0.3377 mL	1.6887 mL
100 mM	0.0169 mL	0.0844 mL	0.1689 mL	0.8444 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc