Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CM121 is a reversible inhibitor of ALDH1A2 that acts specifically on the active site, exhibiting an IC50 of 0.54 μM and a Kd of 1.1 μM. It exerts its inhibitory effect through multiple hydrophobic interactions.
Pack Size | Availability | Price/USD | Quantity |
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5 mg | Inquiry | $ 970.00 |
Description | CM121 is a reversible inhibitor of ALDH1A2 that acts specifically on the active site, exhibiting an IC50 of 0.54 μM and a Kd of 1.1 μM. It exerts its inhibitory effect through multiple hydrophobic interactions. |
Targets&IC50 | ALDH1A2:0.54 μM (IC50), ALDH1A2:Kd: 1.1 μM |
In vitro | CM121 engages with the main-chain amides of Cys320 and Thr321, as well as the side-chains of Thr321 and Asn187, through its methylsulfonyl oxygen. Moreover, CM121 forms π-π stacking interactions with the side chains of PHE188 and PHE314 via its methylsulfonyl benzene and benzylonitrile rings[1]. |
Synonyms | CM121 |
Molecular Weight | 460.48 |
Formula | C24H17FN4O3S |
CAS No. | 2204230-40-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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CM121 2204230-40-8 CM-121 CM 121 inhibitor inhibit