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CM-675

Catalog No. T10841   CAS 1872466-47-1

CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to treat Alzheimer’s disease.

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CM-675 Chemical Structure
CM-675, CAS 1872466-47-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 97.00
2 mg In stock $ 146.00
5 mg In stock $ 247.00
10 mg In stock $ 397.00
25 mg In stock $ 663.00
50 mg In stock $ 945.00
100 mg In stock $ 1,280.00
1 mL * 10 mM (in DMSO) In stock $ 272.00
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Purity: 99.67%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to treat Alzheimer’s disease.
Targets&IC50 PDE5:114 nM nM
In vitro CM-675 (29a) exhibits a significant time-dependent effect on class I HDAC inhibition, particularly towards HDAC2. For HDAC1, its inhibitory potency also increased significantly (~1 log unit) with the pre-incubation time: 673 nM (30 min), 180 nM (4 hours), and 69 nM (6 hours)[1].
Molecular Weight 536.62
Formula C31H32N6O3
CAS No. 1872466-47-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5mg/mL (41.9mM), ultrasonic and warming and heat to 60°C

TargetMolReferences and Literature

1. Rabal O, et al. Discovery of in Vivo Chemical Probes for Treating Alzheimer's Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors. ACS Chem Neurosci. 2019 Mar 20;10(3):1765-1782.

Related compound libraries

This product is contained In the following compound libraries:
Chromatin Modification Compound Library Epigenetics Compound Library Inhibitor Library DNA Damage & Repair Compound Library Bioactive Compound Library Anti-Cancer Compound Library NF-κB Signaling Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets
HDAC6-IN-25 Entinostat HDAC6-IN-24 SS-208 ITSA-1 LMK-235 PRO-HD3 HDAC-IN-7

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Keywords

CM-675 1872466-47-1 Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism PDE HDAC CM675 CM 675 inhibitor inhibit

 

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