Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to treat Alzheimer’s disease.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 97.00 | |
2 mg | In stock | $ 146.00 | |
5 mg | In stock | $ 247.00 | |
10 mg | In stock | $ 397.00 | |
25 mg | In stock | $ 663.00 | |
50 mg | In stock | $ 945.00 | |
100 mg | In stock | $ 1,280.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 272.00 |
Description | CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to treat Alzheimer’s disease. |
Targets&IC50 | PDE5:114 nM nM |
In vitro | CM-675 (29a) exhibits a significant time-dependent effect on class I HDAC inhibition, particularly towards HDAC2. For HDAC1, its inhibitory potency also increased significantly (~1 log unit) with the pre-incubation time: 673 nM (30 min), 180 nM (4 hours), and 69 nM (6 hours)[1]. |
Molecular Weight | 536.62 |
Formula | C31H32N6O3 |
CAS No. | 1872466-47-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5mg/mL (41.9mM), ultrasonic and warming and heat to 60°C
You can also refer to dose conversion for different animals. More
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CM-675 1872466-47-1 Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism PDE HDAC CM675 CM 675 inhibitor inhibit