Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CK2 inhibitor 3 is a highly potent inhibitor of protein kinase CK2, exhibiting an IC50 value of 280 nM. It effectively inhibits the intracellular activity of CK2 and displays a notable impact on the viability of tumor cells. Moreover, CK2 inhibitor 3 demonstrates exceptional selectivity among a diverse panel of 320 kinases [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,520.00 | |
50 mg | 10-14 weeks | $ 1,980.00 | |
100 mg | 10-14 weeks | $ 2,500.00 |
Description | CK2 inhibitor 3 is a highly potent inhibitor of protein kinase CK2, exhibiting an IC50 value of 280 nM. It effectively inhibits the intracellular activity of CK2 and displays a notable impact on the viability of tumor cells. Moreover, CK2 inhibitor 3 demonstrates exceptional selectivity among a diverse panel of 320 kinases [1]. |
In vitro | CK2 inhibitor 3 (compound 4) prominently diminishes cell viability in Jurkat cells in a dose-dependent manner upon exposure to concentrations ranging from 0 to 50 μM for 24 hours, with a DC50 value of 12.80 μM [1]. Moreover, at concentrations of 5 μM and 20 μM over 16 hours, this compound notably decreases the level of CK2-dependent phospho-site Akt Ser129, underscoring its targeted efficacy. These outcomes are drawn from meticulous studies inclusive of a Cell Viability Assay, noting significant reductions in cell viability correlated with dosage, and a Western Blot Analysis that confirms the decrease in Akt Ser129 phosphorylation specific to CK2 activity [1]. |
Molecular Weight | 381.2 |
Formula | C13H9BrN4O3S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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CK2 inhibitor 3 inhibitor inhibit