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CHIR98014 HCl (252935-94-7 free base)

Catalog No. T3074L CAS T3074L

Synonyms: CT-98014, CHIR-98014 hydrochloride, CHIR-98014, CHIR98014 HCl, CHIR98014, CHIR 98014

CHIR98014 is a reversible, cell-permeable inhibitor of GSK3α and GSK3β (IC50s: 0.65 and 0.58 nM). Through its effects on GSK3, CHIR98014 stimulates glycogen synthase in cells (EC50: 106 nM), potentiates insulin-dependent glucose transport in isolated muscle strips, and improves glucose disposal in diabetic animals.

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CHIR98014 HCl (252935-94-7 free base) Chemical Structure

CHIR98014 HCl (252935-94-7 free base), CAS T3074L

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	CT-98014, CHIR-98014 hydrochloride, CHIR-98014, CHIR98014 HCl, CHIR98014, CHIR 98014
Molecular Weight	559.23
Formula	C20H19Cl4N9O2
CAS No.	T3074L

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Qiu YS, Jiang NN, Zhou Y, Yu KY, Gong HY, Liao GJ. LMO3 promotes gastric cancer cell invasion and proliferation through Akt-mTOR and Akt-GSK3β signaling. Int J Mol Med. 2018 May;41(5):2755-2763. doi: 10.3892/ijmm.2018.3476. Epub 2018 Feb 8. PubMed PMID: 29436606; PubMed Central PMCID: PMC5846634. 2. Zajkowski T, Nieznanska H, Nieznanski K. Stabilization of microtubular cytoskeleton protects neurons from toxicity of N-terminal fragment of cytosolic prion protein. Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2228-39. doi: 10.1016/j.bbamcr.2015.07.002. Epub 2015 Jul 3. PubMed PMID: 26149502. 3. Lian X, Bao X, Al-Ahmad A, Liu J, Wu Y, Dong W, Dunn KK, Shusta EV, Palecek SP. Efficient differentiation of human pluripotent stem cells to endothelial progenitors via small-molecule activation of WNT signaling. Stem Cell Reports. 2014 Nov 11;3(5):804-16. doi: 10.1016/j.stemcr.2014.09.005. Epub 2014 Oct 9. Erratum in: Stem Cell Reports. 2015 Jan 13;4(1):170. PubMed PMID: 25418725; PubMed Central PMCID: PMC4235141. 4. Naujok O, Lentes J, Diekmann U, Davenport C, Lenzen S. Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors. BMC Res Notes. 2014 Apr 29;7:273. doi: 10.1186/1756-0500-7-273. PubMed PMID: 24779365; PubMed Central PMCID: PMC4008422.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CHIR98014 HCl (252935-94-7 free base) T3074L 252935-94-7 free base CT-98014 CHIR-98014 hydrochloride CHIR-98014 CT98014 CHIR98014 HCl (252935947 free base) 252935-94-7 CHIR 98014 Hydrochloride CHIR98014 HCl CHIR98014 HCl (252935 94 7 free base) CHIR-98014 Hydrochloride CHIR-98014 HCl (252935-94-7 free base) CT 98014 CHIR98014 CHIR98014 Hydrochloride CHIR 98014 inhibitor inhibit

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