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CGP 55845 hydrochloride

Catalog No. T21759 CAS 149184-22-5

CGP55845 hydrochloride is a potent and selective GABAB receptor antagonist with an IC 50 of 6 nM which can be used in neurological research [1] [2].

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CGP 55845 hydrochloride Chemical Structure

CGP 55845 hydrochloride, CAS 149184-22-5

Pack Size	Availability	Price/USD	Quantity
10 mg	35 days	$ 673.00
50 mg	35 days	$ 2,910.00

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Description	CGP55845 hydrochloride is a potent and selective GABAB receptor antagonist with an IC 50 of 6 nM which can be used in neurological research [1] [2].
In vitro	In the mouse visual cortex, CGP 55845 hydrochloride at a concentration of 1 μM augments the frequency of both spontaneous calcium (Ca 2+) transients and inhibitory postsynaptic currents (IPSCs), including miniature IPSCs (mIPSCs), without altering the amplitude or kinetics of mIPSCs. Additionally, this compound significantly elevates the amplitudes of evoked IPSCs (eIPSCs) and reduces the paired-pulse ratio (PPR), indicating its potent effect on synaptic transmission [3].
In vivo	Administering 0.5 mg/kg of CGP55845 hydrochloride intraperitoneally (i.p.; once) to Cdkl5 KO mice enhances the quantity and density of PSD95-positive puncta, alongside the development and maturation of dendritic spines within the perirhinal cortex (PRC). This treatment also reinstates novel object recognition (NOR) memory. The study utilized 2-month-old male Cdkl5 +/Y and Cdkl5 -/Y mice, observing a notable improvement in NOR memory in the Cdkl5 -/Y mice.

Molecular Weight	438.71
Formula	C18H23Cl3NO3P
CAS No.	149184-22-5

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

CGP 55845 hydrochloride 149184-22-5 CGP-55845 Hydrochloride CGP 55845 Hydrochloride CGP55845 Hydrochloride inhibitor inhibit

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