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CGP-28014

Catalog No. T26997 CAS 111757-17-6

CGP-28014 is an inhibitor of catechol-O-methyltransferase. CGP-28014 increases the renal excretion of both dopamine and dihydroxyphenylacetic acid (DOPAC) but does not affect renal sodium handling indicating a different mechanism of action. CGP-28014 significantly reduced the levels of homovanillic acid (HVA), but did not modify DA and 3,4-dihydroxyphenylacetic acid (DOPAC).

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CGP-28014, CAS 111757-17-6

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	221.3
Formula	C12H19N3O
CAS No.	111757-17-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Kambur O, Talka R, Ansah OB, Kontinen VK, Pertovaara A, Kalso E, Männistö PT. Inhibitors of catechol-O-methyltransferase sensitize mice to pain. Br J Pharmacol. 2010 Dec;161(7):1553-65. doi: 10.1111/j.1476-5381.2010.00999.x. PubMed PMID: 20726980; PubMed Central PMCID: PMC3010567. 2. Hansell P, Odlind C, Männistö PT. Different renal effects of two inhibitors of catechol-O-methylation in the rat: entacapone and CGP 28014. Acta Physiol Scand. 1998 Apr;162(4):489-94. PubMed PMID: 9597116. 3. Männistö PT. Catechol O-methyltransferase: characterization of the protein, its gene, and the preclinical pharmacology of COMT inhibitors. Adv Pharmacol. 1998;42:324-8. PubMed PMID: 9327906. 4. Psylla M, Günther I, Antonini A, Vontobel P, Reist HW, Zollinger A, Leenders KL. Cerebral 6-[18F]fluoro-L-DOPA uptake in rhesus monkey: pharmacological influence of aromatic amino acid decarboxylase (AAAD) and catechol-O-methyltransferase (COMT) inhibition. Brain Res. 1997 Aug 29;767(1):45-54. PubMed PMID: 9365014.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CGP-28014 111757-17-6 CGP 28014 CGP28014 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.