Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM). CDK4/6 inhibitor is a class of compounds used for the treatment of some types of hormone receptor positive, HER2-negative breast cancer, which can block the process of breast cancer cell division and reproduction.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 329.00 | |
5 mg | In stock | $ 798.00 | |
10 mg | In stock | $ 1,090.00 | |
25 mg | In stock | $ 1,650.00 | |
50 mg | In stock | $ 2,230.00 | |
100 mg | In stock | $ 2,930.00 |
Description | CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM). CDK4/6 inhibitor is a class of compounds used for the treatment of some types of hormone receptor positive, HER2-negative breast cancer, which can block the process of breast cancer cell division and reproduction. |
Targets&IC50 | CDK4:3 nM , CDK6:1 nM , CDK4:3 nM, CDK6:1 nM |
In vitro | CDK4/6/1 Inhibitor is an anti-proliferative agent that arrests the U87MG cell line exclusively in G1 (IC50=15.3 nM in the anti-proliferation assay). U87MG cells exposed to varying concentrations of CDK4/6/1 Inhibitor for 24 hours show a dose-related increase in G1 arrest, and a significant increase in the percentage of cells in G1 is found in as little as 13.72 nM of CDK4/6/1 Inhibitor.[1] |
In vivo | In an orthotopic xenograft mouse model of glioblastoma multiforme, CDK4/6/1 Inhibitor (3.125 to 50 mg/kg) has tumor growth inhibition values ranging from 62% to 99%, and no significant body weight loss is observed. The increase in life span based on the median survival time of vehicle-treated animals in mice administered a dose of 50 mg/kg is significant at 162%.[1] |
Synonyms | Crozbaciclib |
Molecular Weight | 488.57 |
Formula | C28H30F2N6 |
CAS No. | 2099128-41-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Slightly soluble
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CDK4/6/1 Inhibitor 2099128-41-1 Cell Cycle/Checkpoint CDK Crozbaciclib inhibitor inhibit