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CAY10784

Catalog No. T36035 CAS 1245814-52-1

CAY10784 is a STAT3 inhibitor (IC50= 0.74 μM in a reporter assay) and a derivative of WP1066 .1It inhibits proliferation of HeLa, Caco-2, A549, A375, U87MG, and HL-60 cancer cells (IC50s = 1.8, 1.8, 3, 2.8, 2.3, and 1.2 μM, respectively) but not PC3 or HT-29 cancer cells (IC50s = <10 μM for both). CAY10784 is also active againstH. pyloriandC. jejuni(MICs = 1.6 and 4.7 μM, respectively).2

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CAY10784, CAS 1245814-52-1

Pack Size	Availability	Price/USD
1 mg	35 days	$ 143.00
5 mg	35 days	$ 583.00
10 mg	35 days	$ 1,090.00
25 mg	35 days	$ 2,390.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

CAY10784 is a STAT3 inhibitor (IC50= 0.74 μM in a reporter assay) and a derivative of WP1066 .1It inhibits proliferation of HeLa, Caco-2, A549, A375, U87MG, and HL-60 cancer cells (IC50s = 1.8, 1.8, 3, 2.8, 2.3, and 1.2 μM, respectively) but not PC3 or HT-29 cancer cells (IC50s = >10 μM for both). CAY10784 is also active againstH. pyloriandC. jejuni(MICs = 1.6 and 4.7 μM, respectively).2

Molecular Weight	317.24
Formula	C11H6F3N3O3S
CAS No.	1245814-52-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMF:PBS (pH 7.2) (1:2): 0.33 mg/mL

DMSO: 10 mg/mL

Ethanol: 1 mg/mL

DMF: 30 mg/mL

References and Literature

1. Lü, Z., Li, X., Li, K., et al.Structure-activity study of nitazoxanide derivatives as novel STAT3 pathway inhibitorsACS Med. Chem. Lett.(2021) 2. Ballard, T.E., Wang, X., Olekhnovich, I., et al.Synthesis and antimicrobial evaluation of nitazoxanide-based analogues: Identification of selective and broad spectrum activityChemMedChem6(2)362-377(2011)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CAY10784 1245814-52-1 CAY-10784 CAY 10784 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.