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Bucindolol hydrochloride

Catalog No. T26920   CAS 70369-47-0
Synonyms: MJ 131051, Bucindolol HCl, MJ131051, MJ-13105-1, MJ-131051

Bucindolol is a beta-adrenergic receptor antagonist. Bucindolol is a fourth-generation β-blocker. Bucindolol prevented new-onset AF; β₁ and α(2c) polymorphisms predicted therapeutic response; and the 47% of patients who were β₁389 Arg homozygotes had an enhanced effect size of 74%.

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Bucindolol hydrochloride Chemical Structure
Bucindolol hydrochloride, CAS 70369-47-0
Pack Size Availability Price/USD Quantity
25 mg 6-8 weeks $ 1,520.00
50 mg 6-8 weeks $ 1,980.00
100 mg 6-8 weeks $ 2,500.00
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Bucindolol is a beta-adrenergic receptor antagonist. Bucindolol is a fourth-generation β-blocker. Bucindolol prevented new-onset AF; β₁ and α(2c) polymorphisms predicted therapeutic response; and the 47% of patients who were β₁389 Arg homozygotes had an enhanced effect size of 74%.
Synonyms MJ 131051, Bucindolol HCl, MJ131051, MJ-13105-1, MJ-131051
Molecular Weight 399.91
Formula C22H26ClN3O2
CAS No. 70369-47-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Black-Maier E, Steinberg BA, Piccini JP. Bucindolol hydrochloride in atrial fibrillation and concomitant heart failure. Expert Rev Cardiovasc Ther. 2015 Jun;13(6):627-36. doi: 10.1586/14779072.2015.1031111. Epub 2015 May 11. Review. PubMed PMID: 25959096. 2. Aleong RG, Sauer WH, Sauer WH, Murphy GA, Port JD, Anand IS, Fiuzat M, O'Connor CM, Abraham WT, Liggett SB, Bristow MR. Prevention of atrial fibrillation by bucindolol is dependent on the beta₁389 Arg/Gly adrenergic receptor polymorphism. JACC Heart Fail. 2013 Aug;1(4):338-44. PubMed PMID: 24159564; PubMed Central PMCID: PMC3804380. 3. Lymperopoulos A, Negussie S, Walklett K. β1- and α2C-adrenergic receptor polymorphisms and the antiarrhythmic effect of bucindolol in heart failure with reduced ejection fraction. Pharmacogenomics. 2013 Oct;14(13):1545-9. doi: 10.2217/pgs.13.137. PubMed PMID: 24088125. 4. Aleong RG, Sauer WH, Robertson AD, Liggett SB, Bristow MR. Adrenergic receptor polymorphisms and prevention of ventricular arrhythmias with bucindolol in patients with chronic heart failure. Circ Arrhythm Electrophysiol. 2013 Feb;6(1):137-43. doi: 10.1161/CIRCEP.111.969618. Epub 2012 Dec 30. PubMed PMID: 23275278.

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Keywords

Bucindolol hydrochloride 70369-47-0 MJ 131051 Bucindolol HCl MJ131051 MJ-13105-1 MJ-131051 Bucindolol Hydrochloride inhibitor inhibit

 

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