Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bradanicline is a potent and highly selective agonist of the α7 nicotinic acetylcholine receptor (nAChR) with an EC50 of 17 nM and a Ki of 1.4 nM for the human α7 nAChR. It is primarily employed in research pertaining to cognitive disorders [1] [2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,080.00 | |
50 mg | 6-8 weeks | $ 1,410.00 | |
100 mg | 6-8 weeks | $ 2,110.00 |
Description | Bradanicline is a potent and highly selective agonist of the α7 nicotinic acetylcholine receptor (nAChR) with an EC50 of 17 nM and a Ki of 1.4 nM for the human α7 nAChR. It is primarily employed in research pertaining to cognitive disorders [1] [2]. |
In vitro | Bradanicline demonstrates a significant distinction, with over a thousand-fold difference in affinity towards α7 and α4β2 receptor subtypes, without any observable impact on muscle or ganglionic nicotinic receptor subtypes. This indicates a pronounced selectivity for the central nervous system as opposed to the peripheral nervous system [1]. |
In vivo | Bradanicline (0.1-1 mg/kg) demonstrates effectiveness in mitigating both the positive and negative symptoms, as well as the cognitive impairments, associated with schizophrenia in animal models [2]. |
Molecular Weight | 361.44 |
Formula | C22H23N3O2 |
CAS No. | 639489-84-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Bradanicline 639489-84-2 inhibitor inhibit