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Bharangin

Catalog No. T26790 CAS 72711-84-3

Bharangin is a inhibitor of penicillinase enzyme in E coli.

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Bharangin, CAS 72711-84-3

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 2,120.00
50 mg	8-10 weeks	$ 2,780.00
100 mg	8-10 weeks	$ 3,700.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Bharangin is a inhibitor of penicillinase enzyme in E coli.

Molecular Weight	328.4
Formula	C20H24O4
CAS No.	72711-84-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Murthy MM, Subramanyam M, Giridhar KV, Jetty A. Antimicrobial activities of bharangin from Premna herbaceae Roxb. and bharangin monoacetate. J Ethnopharmacol. 2006 Mar 8;104(1-2):290-2. Epub 2005 Oct 27. PubMed PMID: 16257159. 2. Sathish T, Brahmaiah P, Sathya K, Bhojaraju P, Naik NG, Kezia D, Prakasam RS. A novel RP-HPLC method for the determination of bharangin in Ghantu bharangi crude extracts. Pak J Pharm Sci. 2009 Jan;22(1):68-73. PubMed PMID: 19168424. 3. Gupta SC, Kannappan R, Kim J, Rahman GM, Francis SK, Raveendran R, Nair MS, Das J, Aggarwal BB. Bharangin, a diterpenoid quinonemethide, abolishes constitutive and inducible nuclear factor-κB (NF-κB) activation by modifying p65 on cysteine 38 residue and reducing inhibitor of nuclear factor-κB α kinase activation, leading to suppression of NF-κB-regulated gene expression and sensitization of tumor cells to chemotherapeutic agents. Mol Pharmacol. 2011 Nov;80(5):769-81. doi: 10.1124/mol.111.073122. Epub 2011 Jul 27. PubMed PMID: 21795584; PubMed Central PMCID: PMC3198918. 4. Lakshmi VV, Sridhar P, Polasa H. Loss of plasmid linked antibiotic resistance in Escherichia coli on treatment with some phenolic compounds. FEMS Microbiol Lett. 1989 Feb;57(3):275-8. PubMed PMID: 2656388.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bharangin 72711-84-3 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.