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Besifloxacin Hydrochloride

Catalog No. T6406 CAS 405165-61-9

Synonyms: BOL-303224-A, Besivance hydrochloride, Besifloxacin HCl

Besifloxacin Hydrochloride (BOL-303224-A) is a fourth-generation fluoroquinolone antibiotic.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Besifloxacin Hydrochloride Chemical Structure

Besifloxacin Hydrochloride, CAS 405165-61-9

Pack Size	Availability	Price/USD
5 mg	In stock	$ 32.00
10 mg	In stock	$ 52.00
25 mg	In stock	$ 98.00
50 mg	In stock	$ 175.00
100 mg	In stock	$ 335.00
200 mg	In stock	$ 495.00
500 mg	In stock	$ 789.00
1 mL * 10 mM (in DMSO)	In stock	$ 44.00

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Purity: 99.95%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Besifloxacin Hydrochloride (BOL-303224-A) is a fourth-generation fluoroquinolone antibiotic.
In vitro	Besifloxacin has effectively bactericidal activity against prevalent and drug-resistant pathogens. Besifloxacin is the most potent agent tested against gram-positive pathogens and anaerobes and is generally equivalent to comparator fluoroquinolones in activity against most gram-negative pathogens. Besifloxacin demonstrates potent, broad-spectrum activity, which is particularly notable against gram-positive and gram-negative isolates that are resistant to other fluoroquinolones and classes of antibacterial agents.
Kinase Assay	20 ng of purified human DDK, together with increasing concentrations of each DDK inhibitor is pre-incubated for 5 min. Then 10 μCi (γ)-32P ATP and 1.5 μM cold ATP are added in a buffer containing 50 mM Tris-HCl (pH 7.5), 10 mM MgCl2, and 1 mM DTT and incubated for 30 min at 30°C. The proteins are denatured in 1X Laemmli buffer at 100°C followed by SDS-PAGE and autoradiography on HyBlot CL film. DDK kinase activity is indicated by Auto-phosphorylation of DDK. 32P-labeled bands are quantified using ImageJ and the IC50 values are calculated using GraphPad.

Synonyms	BOL-303224-A, Besivance hydrochloride, Besifloxacin HCl
Molecular Weight	430.3
Formula	C19H21ClFN3O3·HCl
CAS No.	405165-61-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11 mg/mL (25.56 mM)

References and Literature

1. McDonald MB, et al. Ophthalmology, 2009, 116(9), 1615-1623. 2. Haas W, et al, Antimicrob Agents Chemother, 2009, 53(8), 3552-3560.

Citations

1. Kaduk J A, Gates-Rector S, Blanton T N.Crystal structure of besifloxacin hydrochloride, C19H22ClFN3O3Cl.Powder Diffraction.2023: 1-10.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-Infection Compound Library Preclinical Compound Library Bioactive Compounds Library Max Bioactive Compound Library Approved Drug Library Anti-Viral Compound Library NO PAINS Compound Library Anti-Bacterial Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Besifloxacin Hydrochloride 405165-61-9 Microbiology/Virology Antibiotic Antibacterial BOL-303224-A Besivance hydrochloride Besivance Hydrochloride Besifloxacin HCl Besifloxacin Bacterial Inhibitor inhibit inhibitor

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