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Bendazac

Catalog No. T7807 CAS 20187-55-7

Synonyms: AF-983, Bendazolic acid

Bendazac (Bendazolic acid) is an anticataract drug. It may act by preventing protein denaturation.

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Bendazac, CAS 20187-55-7

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100 mg	In stock	$ 41.00

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Purity: 98.13%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Bendazac (Bendazolic acid) is an anticataract drug. It may act by preventing protein denaturation.

In vitro

Bendazac (bendazac L-lysine and sodium) inhibits the early stages of protein glycation, as well as the formation of fluorescent advanced glycation products.?Bendazac lysine (20 mM) proved to be more effective in inhibiting fluorescence development (67% inhibition) that the corresponding sodium salt (35% inhibition).?No significant differences were found with respect to furosine levels ;?about 40% inhibition was produced with either bendazac lysine or sodium salt bendazac clearly inhibits glycation of human lens crystallins, as can be efficiently monitored by following specific changes in lens protein fluorescence[1]

Synonyms	AF-983, Bendazolic acid
Molecular Weight	282.29
Formula	C16H14N2O3
CAS No.	20187-55-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (212.55 mM)

References and Literature

1. Marques C , Ramalho J S , Pereira P , et al. Bendazac decreases in vitro glycation of human lens crystallins. Decrease of in vitro protein glycation by bendazac[J]. Documenta Ophthalmologica, 1995, 90(4):395-404. 2. Lewis B S , Rixon K C , Harding J J . Bendazac prevents cyanate binding to soluble lens proteins and cyanate-induced phase-separation opacities in vitro: a possible mechanism by which bendazac could delay cataract[J]. Experimental Eye Research, 1986, 43(6):0-979.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Approved Drug Library Human Metabolite Library Drug-induced Liver Injury (DILI) Compound Library NO PAINS Compound Library Bioactive Compound Library ReFRAME Related Library Bioactive Compounds Library Max FDA-Approved & Pharmacopeia Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bendazac 20187-55-7 Others cataractogenic antinecrotic inhibit choleretic protein inflammatory antilipidaemic denaturation AF 983 AF-983 Inhibitor Bendazolic acid AF983 inhibitor

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