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Belumosudil mesylate

Catalog No. T39555 CAS 2109704-99-4

Synonyms: SLx-2119mesylate, KD025 mesylate

Belumosudil mesylate (KD025 mesylate) is a compound that selectively inhibits ROCK2, demonstrating IC50 values of 105 nM for ROCK2 and 24 μM for ROCK1. It possesses anti-fibrotic properties.

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Belumosudil mesylate, CAS 2109704-99-4

Pack Size	Availability	Price/USD	Quantity
2 mg	5 days	$ 39.00
5 mg	5 days	$ 77.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Belumosudil mesylate (KD025 mesylate) is a compound that selectively inhibits ROCK2, demonstrating IC50 values of 105 nM for ROCK2 and 24 μM for ROCK1. It possesses anti-fibrotic properties.
Targets&IC50	ROCK1:24 μM (IC50), ROCK2:105 nM (IC50)
In vitro	Belumosudil (SLx-2119; 40 μM) significantly reduces Tsp-1 and CTGF mRNA levels in PASMC. Additionally, microarray analysis reveals that aRNA from HMVEC treated with Belumosudil exhibits a background five times higher than that of other arrays[1].
In vivo	Belumosudil (KD-025), administered intraperitoneally at doses of 100, 200, or 300 mg/kg, has been shown to reduce infarct volume in a dose-dependent manner following transient middle cerebral artery occlusion. Its efficacy is consistent across different demographics, including aged, diabetic, or female mice, matching or exceeding that observed in normal adult male subjects[2].

Synonyms	SLx-2119mesylate, KD025 mesylate
Molecular Weight	548.62
Formula	C27H28N6O5S
CAS No.	2109704-99-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Boerma, M., et al. Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase. Blood Coagul Fibrinolysis. 2008 Oct;19(7):709-18. 2. Lee, J.H., et al. Selective ROCK2 Inhibition In Focal Cerebral Ischemia. Ann Clin Transl Neurol. 2014 Jan 1;1(1):2-14.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Belumosudil mesylate 2109704-99-4 KD-025 Mesylate SLx-2119mesylate KD 025 Mesylate KD025 Mesylate KD025 mesylate Belumosudil Mesylate inhibitor inhibit

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